Scintigraphic measurement of regional gut transit in idiopathic constipation
In this study, total gut transit and regional colonic transit in patients with idiopathic constipation were measured scintigraphically. Eight patients with severe constipation were studied, none of whom had evidence of abnormal function of the pelvic floor. 99mTc-radiolabeled Amberlite resin particl...
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Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1991-07, Vol.101 (1), p.107-115 |
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description | In this study, total gut transit and regional colonic transit in patients with idiopathic constipation were measured scintigraphically. Eight patients with severe constipation were studied, none of whom had evidence of abnormal function of the pelvic floor. 99mTc-radiolabeled Amberlite resin particles (average diameter, 1 mm; Sigma Chemical Co., St. Louis, MO) with a mixed meal were used to assess gastric emptying and small bowel transit; similar particles labeled with 111In were ingested in a coated capsule that dispersed in the ileocecal region. These were used to quantify colonic transit. Five healthy volunteers were also studied. Two patients showed delayed gastric emptying and two had slow small bowel transit. Seven of the eight patients had slow colonic transit. In five, delay affected the whole colon (“pancolonic inertia”); in two, transit in the ascending and transverse colon was normal, but solids moved through the left colon slowly. Mean colonic transit was also measured using radiopaque markers; this technique identified the patients with slow transit, as shown by measurements of overall colonic transit by simultaneous scintigraphy. However, estimated transit through the ascending and transverse colons was considerably shorter by the radiopaque marker technique. In conclusion, idiopathic constipation is characterized by either exaggerated reservoir functions of the ascending and transverse colons and/or impairment of propulsive function in the descending colon. Particle size may influence the result of regional colonic transit tests. Transit delays in other parts of the gut suggest that, in some patients, the condition may be a more generalized motor dysfunction. |
doi_str_mv | 10.1016/0016-5085(91)90466-X |
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Eight patients with severe constipation were studied, none of whom had evidence of abnormal function of the pelvic floor. 99mTc-radiolabeled Amberlite resin particles (average diameter, 1 mm; Sigma Chemical Co., St. Louis, MO) with a mixed meal were used to assess gastric emptying and small bowel transit; similar particles labeled with 111In were ingested in a coated capsule that dispersed in the ileocecal region. These were used to quantify colonic transit. Five healthy volunteers were also studied. Two patients showed delayed gastric emptying and two had slow small bowel transit. Seven of the eight patients had slow colonic transit. In five, delay affected the whole colon (“pancolonic inertia”); in two, transit in the ascending and transverse colon was normal, but solids moved through the left colon slowly. Mean colonic transit was also measured using radiopaque markers; this technique identified the patients with slow transit, as shown by measurements of overall colonic transit by simultaneous scintigraphy. However, estimated transit through the ascending and transverse colons was considerably shorter by the radiopaque marker technique. In conclusion, idiopathic constipation is characterized by either exaggerated reservoir functions of the ascending and transverse colons and/or impairment of propulsive function in the descending colon. Particle size may influence the result of regional colonic transit tests. Transit delays in other parts of the gut suggest that, in some patients, the condition may be a more generalized motor dysfunction.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/0016-5085(91)90466-X</identifier><identifier>PMID: 2044899</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics ; Adult ; Aged ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biological and medical sciences ; BODY ; Colon - physiology ; Colon - physiopathology ; CONSTIPATION ; Constipation - diagnostic imaging ; Constipation - physiopathology ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; DIAGNOSIS ; DIAGNOSTIC TECHNIQUES ; DIGESTIVE SYSTEM ; DIGESTIVE SYSTEM DISEASES ; DISEASES ; DYNAMIC FUNCTION STUDIES ; ELECTRON CAPTURE RADIOISOTOPES ; Female ; Gastric Emptying ; Gastroenterology. Liver. Pancreas. Abdomen ; GASTROINTESTINAL TRACT ; Gastrointestinal Transit - physiology ; HOURS LIVING RADIOISOTOPES ; Humans ; INDIUM 111 ; INDIUM ISOTOPES ; Indium Radioisotopes ; INTERMEDIATE MASS NUCLEI ; INTERNAL CONVERSION RADIOISOTOPES ; INTESTINES ; ISOMERIC NUCLEI ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; LARGE INTESTINE ; Male ; Medical sciences ; Middle Aged ; MINUTES LIVING RADIOISOTOPES ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANS ; Other diseases. Semiology ; PATIENTS ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide Imaging ; SCINTISCANNING ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; SYMPTOMS ; Technetium ; TECHNETIUM 99 ; TECHNETIUM ISOTOPES ; YEARS LIVING RADIOI</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1991-07, Vol.101 (1), p.107-115</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-60d30d08f8fe256815bd5d63115128783dbfa2ffed1147c6a65b0df1da3c1f333</citedby><cites>FETCH-LOGICAL-c504t-60d30d08f8fe256815bd5d63115128783dbfa2ffed1147c6a65b0df1da3c1f333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/001650859190466X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4940753$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2044899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5508814$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Stivland, Todd</creatorcontrib><creatorcontrib>Camilleri, Michael</creatorcontrib><creatorcontrib>Vassallo, Mario</creatorcontrib><creatorcontrib>Proano, Maritza</creatorcontrib><creatorcontrib>Rath, Doris</creatorcontrib><creatorcontrib>Brown, Manuel</creatorcontrib><creatorcontrib>Thomforde, George</creatorcontrib><creatorcontrib>Pemberton, John</creatorcontrib><creatorcontrib>Phillips, Sidney</creatorcontrib><title>Scintigraphic measurement of regional gut transit in idiopathic constipation</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>In this study, total gut transit and regional colonic transit in patients with idiopathic constipation were measured scintigraphically. Eight patients with severe constipation were studied, none of whom had evidence of abnormal function of the pelvic floor. 99mTc-radiolabeled Amberlite resin particles (average diameter, 1 mm; Sigma Chemical Co., St. Louis, MO) with a mixed meal were used to assess gastric emptying and small bowel transit; similar particles labeled with 111In were ingested in a coated capsule that dispersed in the ileocecal region. These were used to quantify colonic transit. Five healthy volunteers were also studied. Two patients showed delayed gastric emptying and two had slow small bowel transit. Seven of the eight patients had slow colonic transit. In five, delay affected the whole colon (“pancolonic inertia”); in two, transit in the ascending and transverse colon was normal, but solids moved through the left colon slowly. Mean colonic transit was also measured using radiopaque markers; this technique identified the patients with slow transit, as shown by measurements of overall colonic transit by simultaneous scintigraphy. However, estimated transit through the ascending and transverse colons was considerably shorter by the radiopaque marker technique. In conclusion, idiopathic constipation is characterized by either exaggerated reservoir functions of the ascending and transverse colons and/or impairment of propulsive function in the descending colon. Particle size may influence the result of regional colonic transit tests. Transit delays in other parts of the gut suggest that, in some patients, the condition may be a more generalized motor dysfunction.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>Adult</subject><subject>Aged</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BODY</subject><subject>Colon - physiology</subject><subject>Colon - physiopathology</subject><subject>CONSTIPATION</subject><subject>Constipation - diagnostic imaging</subject><subject>Constipation - physiopathology</subject><subject>COUNTING TECHNIQUES</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIAGNOSIS</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DIGESTIVE SYSTEM</subject><subject>DIGESTIVE SYSTEM DISEASES</subject><subject>DISEASES</subject><subject>DYNAMIC FUNCTION STUDIES</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>Female</subject><subject>Gastric Emptying</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>GASTROINTESTINAL TRACT</subject><subject>Gastrointestinal Transit - physiology</subject><subject>HOURS LIVING RADIOISOTOPES</subject><subject>Humans</subject><subject>INDIUM 111</subject><subject>INDIUM ISOTOPES</subject><subject>Indium Radioisotopes</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>INTERNAL CONVERSION RADIOISOTOPES</subject><subject>INTESTINES</subject><subject>ISOMERIC NUCLEI</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>LARGE INTESTINE</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANS</subject><subject>Other diseases. Semiology</subject><subject>PATIENTS</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>SCINTISCANNING</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>SYMPTOMS</subject><subject>Technetium</subject><subject>TECHNETIUM 99</subject><subject>TECHNETIUM ISOTOPES</subject><subject>YEARS LIVING RADIOI</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtrFDEUgENR6lr9By0MRUQfRk9mktnkRZDiDRZ8qELfQjY52UZmkm2SEfrvzXSXffQlh3C-c_sIuaTwgQIdPkJ9Wg6Cv5P0vQQ2DO3dGVlR3om25rpnZHVCXpCXOf8BANkLek7OO2BMSLkim1vjQ_G7pPf33jQT6jwnnDCUJrom4c7HoMdmN5emJB2yL40Pjbc-7nVZKkwMufj6qeAr8tzpMePrY7wgv79--XXzvd38_Pbj5vOmNRxYaQewPVgQTjjs-CAo31puh55STjuxFr3dOt05h5ZStjaDHvgWrKNW94a6vu8vyPWhb6yjVTa-oLmviwQ0RfF6r6CsQm8P0D7FhxlzUZPPBsdRB4xzVgK4FBKWbuwAmhRzTujUPvlJp0dFQS2m1aJRLRqVpOrJtLqrZVfH_vN2QnsqOqqt-TfHvM5Gj67aMz6fMCYZrPky_dMBwyrsr8e03IPBoPVpOcdG__89_gHthZpH</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>Stivland, Todd</creator><creator>Camilleri, Michael</creator><creator>Vassallo, Mario</creator><creator>Proano, Maritza</creator><creator>Rath, Doris</creator><creator>Brown, Manuel</creator><creator>Thomforde, George</creator><creator>Pemberton, John</creator><creator>Phillips, Sidney</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19910701</creationdate><title>Scintigraphic measurement of regional gut transit in idiopathic constipation</title><author>Stivland, Todd ; Camilleri, Michael ; Vassallo, Mario ; Proano, Maritza ; Rath, Doris ; Brown, Manuel ; Thomforde, George ; Pemberton, John ; Phillips, Sidney</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-60d30d08f8fe256815bd5d63115128783dbfa2ffed1147c6a65b0df1da3c1f333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>Adult</topic><topic>Aged</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BODY</topic><topic>Colon - physiology</topic><topic>Colon - physiopathology</topic><topic>CONSTIPATION</topic><topic>Constipation - diagnostic imaging</topic><topic>Constipation - physiopathology</topic><topic>COUNTING TECHNIQUES</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DIAGNOSIS</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DIGESTIVE SYSTEM</topic><topic>DIGESTIVE SYSTEM DISEASES</topic><topic>DISEASES</topic><topic>DYNAMIC FUNCTION STUDIES</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>Female</topic><topic>Gastric Emptying</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>GASTROINTESTINAL TRACT</topic><topic>Gastrointestinal Transit - physiology</topic><topic>HOURS LIVING RADIOISOTOPES</topic><topic>Humans</topic><topic>INDIUM 111</topic><topic>INDIUM ISOTOPES</topic><topic>Indium Radioisotopes</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>INTERNAL CONVERSION RADIOISOTOPES</topic><topic>INTESTINES</topic><topic>ISOMERIC NUCLEI</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>LARGE INTESTINE</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANS</topic><topic>Other diseases. Semiology</topic><topic>PATIENTS</topic><topic>RADIOISOTOPE SCANNING</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>SCINTISCANNING</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>SYMPTOMS</topic><topic>Technetium</topic><topic>TECHNETIUM 99</topic><topic>TECHNETIUM ISOTOPES</topic><topic>YEARS LIVING RADIOI</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stivland, Todd</creatorcontrib><creatorcontrib>Camilleri, Michael</creatorcontrib><creatorcontrib>Vassallo, Mario</creatorcontrib><creatorcontrib>Proano, Maritza</creatorcontrib><creatorcontrib>Rath, Doris</creatorcontrib><creatorcontrib>Brown, Manuel</creatorcontrib><creatorcontrib>Thomforde, George</creatorcontrib><creatorcontrib>Pemberton, John</creatorcontrib><creatorcontrib>Phillips, Sidney</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stivland, Todd</au><au>Camilleri, Michael</au><au>Vassallo, Mario</au><au>Proano, Maritza</au><au>Rath, Doris</au><au>Brown, Manuel</au><au>Thomforde, George</au><au>Pemberton, John</au><au>Phillips, Sidney</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scintigraphic measurement of regional gut transit in idiopathic constipation</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>101</volume><issue>1</issue><spage>107</spage><epage>115</epage><pages>107-115</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>In this study, total gut transit and regional colonic transit in patients with idiopathic constipation were measured scintigraphically. Eight patients with severe constipation were studied, none of whom had evidence of abnormal function of the pelvic floor. 99mTc-radiolabeled Amberlite resin particles (average diameter, 1 mm; Sigma Chemical Co., St. Louis, MO) with a mixed meal were used to assess gastric emptying and small bowel transit; similar particles labeled with 111In were ingested in a coated capsule that dispersed in the ileocecal region. These were used to quantify colonic transit. Five healthy volunteers were also studied. Two patients showed delayed gastric emptying and two had slow small bowel transit. Seven of the eight patients had slow colonic transit. In five, delay affected the whole colon (“pancolonic inertia”); in two, transit in the ascending and transverse colon was normal, but solids moved through the left colon slowly. Mean colonic transit was also measured using radiopaque markers; this technique identified the patients with slow transit, as shown by measurements of overall colonic transit by simultaneous scintigraphy. However, estimated transit through the ascending and transverse colons was considerably shorter by the radiopaque marker technique. In conclusion, idiopathic constipation is characterized by either exaggerated reservoir functions of the ascending and transverse colons and/or impairment of propulsive function in the descending colon. Particle size may influence the result of regional colonic transit tests. Transit delays in other parts of the gut suggest that, in some patients, the condition may be a more generalized motor dysfunction.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2044899</pmid><doi>10.1016/0016-5085(91)90466-X</doi><tpages>9</tpages></addata></record> |
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subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics Adult Aged BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BODY Colon - physiology Colon - physiopathology CONSTIPATION Constipation - diagnostic imaging Constipation - physiopathology COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DIAGNOSIS DIAGNOSTIC TECHNIQUES DIGESTIVE SYSTEM DIGESTIVE SYSTEM DISEASES DISEASES DYNAMIC FUNCTION STUDIES ELECTRON CAPTURE RADIOISOTOPES Female Gastric Emptying Gastroenterology. Liver. Pancreas. Abdomen GASTROINTESTINAL TRACT Gastrointestinal Transit - physiology HOURS LIVING RADIOISOTOPES Humans INDIUM 111 INDIUM ISOTOPES Indium Radioisotopes INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES INTESTINES ISOMERIC NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPES LARGE INTESTINE Male Medical sciences Middle Aged MINUTES LIVING RADIOISOTOPES NUCLEI ODD-EVEN NUCLEI ORGANS Other diseases. Semiology PATIENTS RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging SCINTISCANNING Stomach. Duodenum. Small intestine. Colon. Rectum. Anus SYMPTOMS Technetium TECHNETIUM 99 TECHNETIUM ISOTOPES YEARS LIVING RADIOI |
title | Scintigraphic measurement of regional gut transit in idiopathic constipation |
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