X-ray structure of an unusual Ca sub 2+ site and the roles of Zn sub 2+ and Ca sup 2+ in the assembly, stability, and storage of the insulin hexamer

Metal ion binding to the insulin hexamer has been investigated by crystallographic analysis. Cadmium, lead, and metal-free hexamers have been refined to R values of 0.181, 0.172, and 0.172, against the data of 1.9-, 2.5-, and 2.5-{angstrom} resolution, respectively. These structures have been compar...

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