Diode-laser-based optical rotation detector for high-performance liquid chromatography and on-line polarimetric analysis
A simple polarimeter with microdegree sensitivity based on a near-infrared (820 nm) semiconductor diode laser is described, and signal to noise ratio analysis is discussed. With the use of small-volume flow cells (typically 8 {mu}L) its utility as a high-performance liquid chromatography (HPLC) dete...
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| Veröffentlicht in: | Analytical chemistry (Washington) 1989-06, Vol.61 (11), p.1238-1243 |
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| container_end_page | 1243 |
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| container_issue | 11 |
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| container_title | Analytical chemistry (Washington) |
| container_volume | 61 |
| creator | Lloyd, David K Goodall, David M Scrivener, Helen |
| description | A simple polarimeter with microdegree sensitivity based on a near-infrared (820 nm) semiconductor diode laser is described, and signal to noise ratio analysis is discussed. With the use of small-volume flow cells (typically 8 {mu}L) its utility as a high-performance liquid chromatography (HPLC) detector in the gradient elution separation of carbohydrates is shown. Coupled with a UV detector, the HPLC enantiomeric purity determination of D-/L-tryptophan mixtures without chiral separation is demonstrated. On a laboratory-scale system an application from the sugar industry is reported, monitoring molasses flow streams which are opaque at visible wave-lengths. |
| doi_str_mv | 10.1021/ac00186a013 |
| format | Article |
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With the use of small-volume flow cells (typically 8 {mu}L) its utility as a high-performance liquid chromatography (HPLC) detector in the gradient elution separation of carbohydrates is shown. Coupled with a UV detector, the HPLC enantiomeric purity determination of D-/L-tryptophan mixtures without chiral separation is demonstrated. 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Chem</addtitle><description>A simple polarimeter with microdegree sensitivity based on a near-infrared (820 nm) semiconductor diode laser is described, and signal to noise ratio analysis is discussed. With the use of small-volume flow cells (typically 8 {mu}L) its utility as a high-performance liquid chromatography (HPLC) detector in the gradient elution separation of carbohydrates is shown. Coupled with a UV detector, the HPLC enantiomeric purity determination of D-/L-tryptophan mixtures without chiral separation is demonstrated. On a laboratory-scale system an application from the sugar industry is reported, monitoring molasses flow streams which are opaque at visible wave-lengths.</description><subject>400102 - Chemical & Spectral Procedures</subject><subject>Analytical chemistry</subject><subject>CARBOHYDRATES</subject><subject>Chemistry</subject><subject>CHROMATOGRAPHY</subject><subject>ENANTIOMORPHS</subject><subject>Exact sciences and technology</subject><subject>General, instrumentation</subject><subject>INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY</subject><subject>LASERS</subject><subject>LIQUID COLUMN CHROMATOGRAPHY</subject><subject>MEASURING INSTRUMENTS</subject><subject>MEASURING METHODS</subject><subject>ORGANIC COMPOUNDS</subject><subject>POLARIMETRY</subject><subject>SEMICONDUCTOR DEVICES</subject><subject>SEMICONDUCTOR LASERS</subject><subject>SEPARATION PROCESSES</subject><subject>SOLID STATE LASERS</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNptkEFLHTEQx4O04Kv11C-wSKEHSZ0ku9l9x6LWFkQFLe0tzMsmbuy-zZpE8H37jmyRHnpIMjC_DP_5MfZBwGcBUpygBRCdRhBqj61EI4HrrpNv2AoAFJctwD57l_MDYQKEXrHnsxB7x0fMLvEN3X0V5xIsjlWKBUuIU9W74myJqfJ0hnA_8Nklqrc4WVeN4fEp9JUdUtxiifcJ52FX4USDJj6GyVVzHDGFrSspWGrguMshv2dvPY7ZHf59D9iPr-d3p9_45fXF99MvlxyV6gpfA4LzQsgaNq72CkF3vZLNulZy3Xkl29qKRnkAdMq6TSMUNLrx1mvpRGvVATta5sZcgsk20C6DjdNEK5mm1p1YdwQdL5BNMefkvJkpMKadEWBezJp_zBL9caFnzCTKJ_IQ8uuXVgkJbU0YX7CQi3t-bWP6bXSr2sbc3dwara5-CophfhH_aeHRZvMQnxKZyv8N8AfdC5Td</recordid><startdate>19890601</startdate><enddate>19890601</enddate><creator>Lloyd, David K</creator><creator>Goodall, David M</creator><creator>Scrivener, Helen</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19890601</creationdate><title>Diode-laser-based optical rotation detector for high-performance liquid chromatography and on-line polarimetric analysis</title><author>Lloyd, David K ; Goodall, David M ; Scrivener, Helen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a338t-90a0ef11240be4f3a068d325943298f3274c153f00ae3ceb5130565fcf62e17c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>400102 - Chemical & Spectral Procedures</topic><topic>Analytical chemistry</topic><topic>CARBOHYDRATES</topic><topic>Chemistry</topic><topic>CHROMATOGRAPHY</topic><topic>ENANTIOMORPHS</topic><topic>Exact sciences and technology</topic><topic>General, instrumentation</topic><topic>INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY</topic><topic>LASERS</topic><topic>LIQUID COLUMN CHROMATOGRAPHY</topic><topic>MEASURING INSTRUMENTS</topic><topic>MEASURING METHODS</topic><topic>ORGANIC COMPOUNDS</topic><topic>POLARIMETRY</topic><topic>SEMICONDUCTOR DEVICES</topic><topic>SEMICONDUCTOR LASERS</topic><topic>SEPARATION PROCESSES</topic><topic>SOLID STATE LASERS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lloyd, David K</creatorcontrib><creatorcontrib>Goodall, David M</creatorcontrib><creatorcontrib>Scrivener, Helen</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lloyd, David K</au><au>Goodall, David M</au><au>Scrivener, Helen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diode-laser-based optical rotation detector for high-performance liquid chromatography and on-line polarimetric analysis</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>1989-06-01</date><risdate>1989</risdate><volume>61</volume><issue>11</issue><spage>1238</spage><epage>1243</epage><pages>1238-1243</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>A simple polarimeter with microdegree sensitivity based on a near-infrared (820 nm) semiconductor diode laser is described, and signal to noise ratio analysis is discussed. With the use of small-volume flow cells (typically 8 {mu}L) its utility as a high-performance liquid chromatography (HPLC) detector in the gradient elution separation of carbohydrates is shown. Coupled with a UV detector, the HPLC enantiomeric purity determination of D-/L-tryptophan mixtures without chiral separation is demonstrated. On a laboratory-scale system an application from the sugar industry is reported, monitoring molasses flow streams which are opaque at visible wave-lengths.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><doi>10.1021/ac00186a013</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2700 |
| ispartof | Analytical chemistry (Washington), 1989-06, Vol.61 (11), p.1238-1243 |
| issn | 0003-2700 1520-6882 |
| language | eng |
| recordid | cdi_osti_scitechconnect_5468198 |
| source | ACS Publications |
| subjects | 400102 - Chemical & Spectral Procedures Analytical chemistry CARBOHYDRATES Chemistry CHROMATOGRAPHY ENANTIOMORPHS Exact sciences and technology General, instrumentation INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY LASERS LIQUID COLUMN CHROMATOGRAPHY MEASURING INSTRUMENTS MEASURING METHODS ORGANIC COMPOUNDS POLARIMETRY SEMICONDUCTOR DEVICES SEMICONDUCTOR LASERS SEPARATION PROCESSES SOLID STATE LASERS |
| title | Diode-laser-based optical rotation detector for high-performance liquid chromatography and on-line polarimetric analysis |
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