The metabolism of pentachlorobenzene by rat liver microsomes: The nature of the reactive intermediates formed

Metabolism of [ 14C]-pentachlorobenzene by liver microsomes from dexamethasone-induced rats results in the formation of pentachlorophenol and 2,3,4,6-tetrachlorphenol as major primary metabolites in a ratio of 4:1, with 2,3,4,5- and 2,3,5,6-tetrachlorophenols as minor metabolites. The unsubstituted...

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Veröffentlicht in:	Biochemical and biophysical research communications 1989-09, Vol.163 (3), p.1275-1281
Hauptverfasser:	den Besten, C., Peters, M.M.C.G., van Bladeren, P.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	550501 - Metabolism- Tracer Techniques 560300 - Chemicals Metabolism & Toxicology ADRENAL HORMONES ANIMALS AROMATICS ASCORBIC ACID BASIC BIOLOGICAL SCIENCES Biotransformation BODY CARBON 14 COMPOUNDS Carbon Radioisotopes CELL CONSTITUENTS CHLORINATED AROMATIC HYDROCARBONS Chlorobenzenes - metabolism CHROMATOGRAPHY Chromatography, High Pressure Liquid CORTICOSTEROIDS DEXAMETHASONE Dexamethasone - pharmacology DIGESTIVE SYSTEM DRUGS ENZYMES GLANDS GLUCOCORTICOIDS GLUTATHIONE HALOGENATED AROMATIC HYDROCARBONS HYDROXY COMPOUNDS Insecticides - metabolism ISOTOPE APPLICATIONS KETONES LABELLED COMPOUNDS LIQUID COLUMN CHROMATOGRAPHY LIVER Male MAMMALS METABOLISM METABOLITES MICROSOMES Microsomes, Liver - drug effects Microsomes, Liver - metabolism MIXED-FUNCTION OXIDASES ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANOIDS ORGANS OXIDOREDUCTASES OXYGENASES PEPTIDES POLYPEPTIDES PREGNANES PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Radioisotope Dilution Technique RADIOPROTECTIVE SUBSTANCES RATS Rats, Inbred Strains RIBOSOMES RODENTS SEPARATION PROCESSES STEROIDS TRACER TECHNIQUES VERTEBRATES VITAMINS
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