Influence of UV Irradiation on the Composition of Human Stratum Corneum Lipids

Irradiation with suberythemal doses of either UV-A or UV-B yielded an increase in the amount of stratum corneum lipids extracted from the lumbar skin area of 20 volunteers. These lipids were quantified after separation by high-performance thin-layer chromatography. Ten subfractions in the ceramide r...

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Veröffentlicht in:	Journal of investigative dermatology 1991-06, Vol.96 (6), p.959-962
Hauptverfasser:	Wefers, Heribert, Melnik, Bodo C., Flür, Martin, Bluhm, Christel, Lehmann, Percy, Plewig, Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture Adult ANIMAL TISSUES ANIMALS Biological and medical sciences BIOLOGICAL EFFECTS Biological effects of radiation BIOLOGICAL RADIATION EFFECTS BIOSYNTHESIS BODY Ceramides - radiation effects CHROMATOGRAPHY Chromatography, Thin Layer ELECTROMAGNETIC RADIATION EPIDERMIS Epidermis - metabolism Epidermis - radiation effects EPITHELIUM Female FRACTIONATED IRRADIATION Fundamental and applied biological sciences. Psychology Humans IRRADIATION Lipid Metabolism LIPIDS Lipids - radiation effects Male MAMMALS MAN Middle Aged Non ionizing radiations. Hertzian waves. Biooptics ORGANIC COMPOUNDS ORGANS PRIMATES RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS SEPARATION PROCESSES SKIN SYNTHESIS THIN-LAYER CHROMATOGRAPHY TISSUES Tissues, organs and organisms biophysics ULTRAVIOLET RADIATION Ultraviolet Rays VERTEBRATES
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Zusammenfassung:	Irradiation with suberythemal doses of either UV-A or UV-B yielded an increase in the amount of stratum corneum lipids extracted from the lumbar skin area of 20 volunteers. These lipids were quantified after separation by high-performance thin-layer chromatography. Ten subfractions in the ceramide region were separated; two of them (fractions 7a and 7b) were only detectable after UV-A or UV-B irradiation. Improvement of barrier function after UV irradiation of human skin with suberythemal doses may be related to an increase in the stratum corneum ceramides.
ISSN:	0022-202X 1523-1747
DOI:	10.1111/1523-1747.ep12476124