Trigramin: primary structure and its inhibition of von Willebrand factor binding to glycoprotein IIb/IIIa complex on human platelets

Trigramin, a naturally occurring peptide purified from Trimeresurus gramineus (T. stejnegeri formosensis) snake venom, inhibits platelet aggregation and the binding of 125I-fibrinogen to ADP-stimulated platelets (Ki = 2 X 10(-8) M) without affecting the platelet-release reaction. 125I-trigramin bind...

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Veröffentlicht in:	Biochemistry (Easton) 1989-01, Vol.28 (2), p.661-666
Hauptverfasser:	Huang, Tur Fu, Holt, John C, Kirby, Edward P, Niewiarowski, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques AMINO ACID SEQUENCE AMINO ACIDS ANIMALS ANTIBODIES ARGININE ASPARTIC ACID BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BLOOD COAGULATION BLOOD PLATELETS BODY FLUIDS CARBOHYDRATES CARBOXYLIC ACIDS CHEMICAL REACTIONS CROSS-LINKING Crotalid Venoms - chemistry DAYS LIVING RADIOISOTOPES ELECTRON CAPTURE RADIOISOTOPES Fibrinogen - antagonists & inhibitors GLUCOPROTEINS GLYCINE GLYCOPROTEINS Humans HYDROXY ACIDS INHIBITION INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES ISOTOPES MATERIALS MEMBRANE PROTEINS Molecular Sequence Data MOLECULAR STRUCTURE MONOCLONAL ANTIBODIES NUCLEI ODD-EVEN NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS Peptide Hydrolases PEPTIDES Peptides - isolation & purification Peptides - pharmacology Platelet Membrane Glycoproteins - metabolism POLYMERIZATION PROTEINS RADIOISOTOPES RECEPTORS REPTILES SACCHARIDES Sequence Homology, Nucleic Acid SERINE SNAKES trigramin Trimeresurus gramineus venom VENOMS VERTEBRATES von Willebrand factor von Willebrand Factor - metabolism
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