Uptake and distribution of sup 14 C during and following inhalation exposure to radioactive toluene diisocyanate

Inhalation of toluene diisocyanate (TDI) results in toxic responses ranging from pulmonary irritation to immunological sensitization. The use of radioactively labeled isocyanate has made it possible to follow the initial uptake of the compound into the bloodstream independent of the final fate of th...

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Veröffentlicht in:	Toxicology and applied pharmacology 1989-09, Vol.100:2
Hauptverfasser:	Kennedy, A.L., Stock, M.F., Alarie, Y., Brown, W.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	550501 - Metabolism- Tracer Techniques 560300 - Chemicals Metabolism & Toxicology ALKYLATED AROMATICS ANIMALS AROMATICS BASIC BIOLOGICAL SCIENCES CARBON 14 COMPOUNDS CARBONIC ACID DERIVATIVES CHROMATOGRAPHY CYANATES DISTRIBUTION GUINEA PIGS HYDROCARBONS INHALATION INTAKE ISOTOPE APPLICATIONS LABELLED COMPOUNDS LIQUID COLUMN CHROMATOGRAPHY MAMMALS MATHEMATICS METABOLISM NITROGEN COMPOUNDS ORGANIC COMPOUNDS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT REGRESSION ANALYSIS RODENTS SEPARATION PROCESSES STATISTICS STRUCTURE-ACTIVITY RELATIONSHIPS TISSUE DISTRIBUTION TOLUENE TOXICITY TRACER TECHNIQUES VERTEBRATES
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