Methylene chloride exposure and birthweight in Monroe County, New York
This study examined the relationship between birthweight and exposure to emissions of methylene chloride (DCM) from manufacturing processes of the Eastman Kodak Company at Kodak Park in Rochester, Monroe County, New York. County census tracts were categorized as exposed to high, moderate, low or no...
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| Veröffentlicht in: | Environmental research 1991-06, Vol.55 (1), p.31-39 |
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| creator | Bell, Beth P. Franks, Peter Hildreth, Nancy Melius, James |
| description | This study examined the relationship between birthweight and exposure to emissions of methylene chloride (DCM) from manufacturing processes of the Eastman Kodak Company at Kodak Park in Rochester, Monroe County, New York. County census tracts were categorized as exposed to high, moderate, low or no DCM based on the Kodak Air Monitoring Program (KAMP) model, a theoretical dispersion model of DCM developed by Eastman Kodak Company. Birthweight and information on variables known to influence birthweight were obtained from 91,302 birth certificates of white singleton births to Monroe County residents from 1976 to 1987. No significant adverse effects of exposure to DCM on birthweight were found. Adjusted birthweight in high exposure census tracts was 18.7 g less than in areas with no exposure (95% confidence interval for the difference between high and no exposure −51.6, 14.2 g). Problems inherent in the method of estimation of exposure, which may decrease power or bias the results, are discussed. Better methods to estimate exposure to emissions from multiple industrial point sources are needed. |
| doi_str_mv | 10.1016/S0013-9351(05)80138-0 |
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County census tracts were categorized as exposed to high, moderate, low or no DCM based on the Kodak Air Monitoring Program (KAMP) model, a theoretical dispersion model of DCM developed by Eastman Kodak Company. Birthweight and information on variables known to influence birthweight were obtained from 91,302 birth certificates of white singleton births to Monroe County residents from 1976 to 1987. No significant adverse effects of exposure to DCM on birthweight were found. Adjusted birthweight in high exposure census tracts was 18.7 g less than in areas with no exposure (95% confidence interval for the difference between high and no exposure −51.6, 14.2 g). Problems inherent in the method of estimation of exposure, which may decrease power or bias the results, are discussed. Better methods to estimate exposure to emissions from multiple industrial point sources are needed.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/S0013-9351(05)80138-0</identifier><identifier>PMID: 1855488</identifier><identifier>CODEN: ENVRAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; Air Pollutants - adverse effects ; AIR POLLUTION ; Biological and medical sciences ; Birth Weight - drug effects ; Chemical and industrial products toxicology. Toxic occupational diseases ; DEVELOPED COUNTRIES ; Environmental Exposure ; FEDERAL REGION II ; Female ; Humans ; Infant, Newborn ; Maternal Age ; MATHEMATICS ; Medical sciences ; METHYLENE CHLORIDE ; Methylene Chloride - adverse effects ; NEW YORK ; NORTH AMERICA ; OCCUPATIONAL EXPOSURE ; ORGANIC CHLORINE COMPOUNDS ; ORGANIC COMPOUNDS ; ORGANIC HALOGEN COMPOUNDS ; PERSONNEL ; POLLUTION ; PREGNANCY ; Pregnancy - drug effects ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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County census tracts were categorized as exposed to high, moderate, low or no DCM based on the Kodak Air Monitoring Program (KAMP) model, a theoretical dispersion model of DCM developed by Eastman Kodak Company. Birthweight and information on variables known to influence birthweight were obtained from 91,302 birth certificates of white singleton births to Monroe County residents from 1976 to 1987. No significant adverse effects of exposure to DCM on birthweight were found. Adjusted birthweight in high exposure census tracts was 18.7 g less than in areas with no exposure (95% confidence interval for the difference between high and no exposure −51.6, 14.2 g). Problems inherent in the method of estimation of exposure, which may decrease power or bias the results, are discussed. Better methods to estimate exposure to emissions from multiple industrial point sources are needed.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>Air Pollutants - adverse effects</subject><subject>AIR POLLUTION</subject><subject>Biological and medical sciences</subject><subject>Birth Weight - drug effects</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>DEVELOPED COUNTRIES</subject><subject>Environmental Exposure</subject><subject>FEDERAL REGION II</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Maternal Age</subject><subject>MATHEMATICS</subject><subject>Medical sciences</subject><subject>METHYLENE CHLORIDE</subject><subject>Methylene Chloride - adverse effects</subject><subject>NEW YORK</subject><subject>NORTH AMERICA</subject><subject>OCCUPATIONAL EXPOSURE</subject><subject>ORGANIC CHLORINE COMPOUNDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC HALOGEN COMPOUNDS</subject><subject>PERSONNEL</subject><subject>POLLUTION</subject><subject>PREGNANCY</subject><subject>Pregnancy - drug effects</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>REGRESSION ANALYSIS</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Solvents</subject><subject>STATISTICS</subject><subject>TERATOGENESIS</subject><subject>Toxicology</subject><subject>USA</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQQC0EKtvCT6hkIYRAImDHsROfEFq1gNTCAThwshx7TAxZe7Edyv57kmZVjpxGo3nz9RA6p-QVJVS8_kwIZZVknD4n_EU3J11F7qENJVJURHJ2H23ukIfoNOcfc0o5IyfohHacN123QZfXUIbDCAGwGcaYvAUMf_YxTwmwDhb3PpXhBvz3oWAf8HUMKQLeximUw0v8EW7wt5h-PkIPnB4zPD7GM_T18uLL9n119endh-3bq8owUZeqldQ5LqEl1tTWNtJpZq2mpO5bC4a3xnaSip6IRvemc72TdcPbXkppeyMcO0NP1rkxF6-y8QXMYGIIYIrijLZC8Bl6tkL7FH9NkIva-WxgHHWAOGVFm7pls5UZ5CtoUsw5gVP75Hc6HRQlapGsbiWrxaAiXN1KVmTuOz8umPod2H9dq9W5_vRY19no0SUdjM93GOdSMrGMebNiMBv77SEtD0EwYH1a_rHR_-eQv8UpmHA</recordid><startdate>199106</startdate><enddate>199106</enddate><creator>Bell, Beth P.</creator><creator>Franks, Peter</creator><creator>Hildreth, Nancy</creator><creator>Melius, James</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>OTOTI</scope></search><sort><creationdate>199106</creationdate><title>Methylene chloride exposure and birthweight in Monroe County, New York</title><author>Bell, Beth P. ; Franks, Peter ; Hildreth, Nancy ; Melius, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-791ff59e70dc2dd49fa3dda102b7dec57cd8916b064abc8fbf92457b999dbc6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>Air Pollutants - adverse effects</topic><topic>AIR POLLUTION</topic><topic>Biological and medical sciences</topic><topic>Birth Weight - drug effects</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>DEVELOPED COUNTRIES</topic><topic>Environmental Exposure</topic><topic>FEDERAL REGION II</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Maternal Age</topic><topic>MATHEMATICS</topic><topic>Medical sciences</topic><topic>METHYLENE CHLORIDE</topic><topic>Methylene Chloride - adverse effects</topic><topic>NEW YORK</topic><topic>NORTH AMERICA</topic><topic>OCCUPATIONAL EXPOSURE</topic><topic>ORGANIC CHLORINE COMPOUNDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC HALOGEN COMPOUNDS</topic><topic>PERSONNEL</topic><topic>POLLUTION</topic><topic>PREGNANCY</topic><topic>Pregnancy - drug effects</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>REGRESSION ANALYSIS</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Solvents</topic><topic>STATISTICS</topic><topic>TERATOGENESIS</topic><topic>Toxicology</topic><topic>USA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bell, Beth P.</creatorcontrib><creatorcontrib>Franks, Peter</creatorcontrib><creatorcontrib>Hildreth, Nancy</creatorcontrib><creatorcontrib>Melius, James</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bell, Beth P.</au><au>Franks, Peter</au><au>Hildreth, Nancy</au><au>Melius, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methylene chloride exposure and birthweight in Monroe County, New York</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>1991-06</date><risdate>1991</risdate><volume>55</volume><issue>1</issue><spage>31</spage><epage>39</epage><pages>31-39</pages><issn>0013-9351</issn><eissn>1096-0953</eissn><coden>ENVRAL</coden><abstract>This study examined the relationship between birthweight and exposure to emissions of methylene chloride (DCM) from manufacturing processes of the Eastman Kodak Company at Kodak Park in Rochester, Monroe County, New York. County census tracts were categorized as exposed to high, moderate, low or no DCM based on the Kodak Air Monitoring Program (KAMP) model, a theoretical dispersion model of DCM developed by Eastman Kodak Company. Birthweight and information on variables known to influence birthweight were obtained from 91,302 birth certificates of white singleton births to Monroe County residents from 1976 to 1987. No significant adverse effects of exposure to DCM on birthweight were found. Adjusted birthweight in high exposure census tracts was 18.7 g less than in areas with no exposure (95% confidence interval for the difference between high and no exposure −51.6, 14.2 g). Problems inherent in the method of estimation of exposure, which may decrease power or bias the results, are discussed. Better methods to estimate exposure to emissions from multiple industrial point sources are needed.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>1855488</pmid><doi>10.1016/S0013-9351(05)80138-0</doi><tpages>9</tpages></addata></record> |
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| subjects | 560300 - Chemicals Metabolism & Toxicology Air Pollutants - adverse effects AIR POLLUTION Biological and medical sciences Birth Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases DEVELOPED COUNTRIES Environmental Exposure FEDERAL REGION II Female Humans Infant, Newborn Maternal Age MATHEMATICS Medical sciences METHYLENE CHLORIDE Methylene Chloride - adverse effects NEW YORK NORTH AMERICA OCCUPATIONAL EXPOSURE ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS PERSONNEL POLLUTION PREGNANCY Pregnancy - drug effects RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT REGRESSION ANALYSIS Retrospective Studies Risk Factors Solvents STATISTICS TERATOGENESIS Toxicology USA |
| title | Methylene chloride exposure and birthweight in Monroe County, New York |
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