Correlation of 125I-LSD autoradiographic labeling with serotonin voltage clamp responses in Aplysia neurons

Autoradiographic receptor binding studies using 125I‐LSD (2‐[125I]lysergic acid diethyamide) revealed intense labelling on the soma of a symmetrically located pair of cells in the abdominal ganglion of Aplysia californica. This binding was blocked by micromolar concentrations of serotonin and lower...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 1991-05, Vol.8 (1), p.22-29
Hauptverfasser:	Evans, Martyn L., Kadan, Michael J., Hartig, Paul R., Carpenter, David O.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques Abdominal ganglion ACETYLCHOLINE Acetylcholine - pharmacology ALKALI METAL COMPOUNDS AMINES AMMONIUM COMPOUNDS ANIMAL CELLS Animals ANIONS Aplysia AROMATICS AUTONOMIC NERVOUS SYSTEM AGENTS AUTORADIOGRAPHY AZAARENES AZOLES BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BIOCHEMICAL REACTION KINETICS CATIONS CENTRAL NERVOUS SYSTEM AGENTS CHARGED PARTICLES CHLORIDES CHLORINE COMPOUNDS COBALT COMPOUNDS Cyproheptadine Cyproheptadine - pharmacology DAYS LIVING RADIOISOTOPES DRUGS Electric Conductivity - drug effects ELECTRON CAPTURE RADIOISOTOPES ELECTROPHYSIOLOGY ESTERS Ganglia - physiology HALIDES HALOGEN COMPOUNDS HETEROCYCLIC COMPOUNDS HYDROXY COMPOUNDS IN VITRO In Vitro Techniques INDOLES INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES IODINE 125 IODINE ISOTOPES Iodine Radioisotopes Ion Channels - drug effects Ion Channels - physiology IONS ISOTOPES KINETICS LABELLING Lysergic Acid Diethylamide - metabolism Membrane Potentials - drug effects MEMBRANE PROTEINS Mianserin Mianserin - pharmacology NERVE CELLS Neurons - drug effects Neurons - physiology NEUROREGULATORS NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS PARASYMPATHOMIMETICS PHYSIOLOGY POTASSIUM COMPOUNDS PROTEINS PSYCHOTROPIC DRUGS PYRROLES QUATERNARY COMPOUNDS RADIOISOTOPES Radioligand Assay RADIOPROTECTIVE SUBSTANCES REACTION KINETICS RECEPTORS Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Receptors, Serotonin - physiology SEROTONIN Serotonin - pharmacology Serotonin 1C receptor SODIUM COMPOUNDS SOMATIC CELLS SYMPATHOMIMETICS TRANSITION ELEMENT COMPOUNDS TRYPTAMINES
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