Ultraviolet mutagenesis in a plasmid vector replicated in lymphoid cells from patient with the melanoma-prone disorder dysplastic nevus syndrome

The hereditary dysplastic nevus syndrome (DNS) is an autosomal dominant disorder in which affected individuals have increased numbers of dysplastic (premalignant) nevi and a greater than 100-fold increased risk of developing cutaneous melanoma. Epstein-Barr virus-transformed lymphoblastoid cell line...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1989-11, Vol.49 (21), p.5918-5921
Hauptverfasser:	Seetharam, S, Waters, H L, Seidman, M M, Kraemer, K H
Format:	Artikel
Sprache:	eng
Schlagworte:	560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture Adult ANIMAL CELLS ANIMALS Base Composition Base Sequence BIOLOGICAL EFFECTS BIOLOGICAL MARKERS BIOLOGICAL MATERIALS BIOLOGICAL RADIATION EFFECTS BLOOD BLOOD CELLS BODY FLUIDS CELL CONSTITUENTS Cell Line CONNECTIVE TISSUE CELLS Disease Susceptibility DISEASES DNA DNA REPLICATION DNA Replication - radiation effects DNA, Neoplasm - genetics DNA, Neoplasm - radiation effects Dysplastic Nevus Syndrome - genetics ELECTROMAGNETIC RADIATION Female FIBROBLASTS GENE MUTATIONS GENES GENETIC EFFECTS GENETIC RADIATION EFFECTS Genetic Vectors Humans LEUKOCYTES LYMPHOCYTES Lymphocytes - cytology MAMMALS MAN MATERIALS Melanoma - genetics MELANOMAS Molecular Sequence Data MUTAGENESIS Mutation MUTATION FREQUENCY MUTATIONS NEOPLASMS NUCLEIC ACID REPLICATION NUCLEIC ACIDS ORGANIC COMPOUNDS PATIENTS PLASMIDS Plasmids - radiation effects PRIMATES RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOINDUCTION SKIN DISEASES SOMATIC CELLS U.V. radiation ULTRAVIOLET RADIATION Ultraviolet Rays VERTEBRATES XERODERMA PIGMENTOSUM
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