Radiation alone in the treatment of cancer of the uterine cervix: Analysis of pelvic failure and dose response relationship
This retrospective analysis involves 569 patients with invasive cancer of the uterine cervix treated with irradiation alone between 1969 and 1980. Treatment consisted of external and intracavitary irradiation and treatment policy remained consistant throughout the study interval. In early stage dise...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 1989-11, Vol.17 (5), p.973-978 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Kim, Robert Y. Trotti, Andy Wu, Ching-Jung Soong, S.J. Salter, Merle M. |
| description | This retrospective analysis involves 569 patients with invasive cancer of the uterine cervix treated with irradiation alone between 1969 and 1980. Treatment consisted of external and intracavitary irradiation and treatment policy remained consistant throughout the study interval. In early stage disease (FIGO IA, III, and IIA), pelvic failure was 4.6%, 11.2%, and 8.2%, respectively. In late stage disease (FIGO IIB, III, and IVA), pelvic failure was 30.1%, 52.3%, and 69.2%, respectively. Further analysis revealed that total dose at point A is well correlated with pelvic control. An aggressive treatment is crucial in late stage disease in determining the probability of pelvic tumor control and survival. Methods of dose prescription, dose-response relationships, treatment philosophy and its therapeutic implications are discussed. |
| doi_str_mv | 10.1016/0360-3016(89)90144-2 |
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Treatment consisted of external and intracavitary irradiation and treatment policy remained consistant throughout the study interval. In early stage disease (FIGO IA, III, and IIA), pelvic failure was 4.6%, 11.2%, and 8.2%, respectively. In late stage disease (FIGO IIB, III, and IVA), pelvic failure was 30.1%, 52.3%, and 69.2%, respectively. Further analysis revealed that total dose at point A is well correlated with pelvic control. An aggressive treatment is crucial in late stage disease in determining the probability of pelvic tumor control and survival. Methods of dose prescription, dose-response relationships, treatment philosophy and its therapeutic implications are discussed.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(89)90144-2</identifier><identifier>PMID: 2808059</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>550603 - Medicine- External Radiation in Therapy- (1980-) ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - radiotherapy ; Adult ; Aged ; Biological and medical sciences ; BODY ; Carcinoma of the cervix ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; DISEASES ; Dose-Response Relationship, Radiation ; DOSE-RESPONSE RELATIONSHIPS ; DOSES ; Female ; Female genital diseases ; FEMALE GENITALS ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; MEDICINE ; Middle Aged ; Neoplasm Staging ; NEOPLASMS ; NUCLEAR MEDICINE ; ORGANS ; PATIENTS ; Pelvic failure ; Pelvic Neoplasms - secondary ; RADIATION DOSES ; Radiation treatment ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Retrospective Studies ; SURVIVAL CURVES ; THERAPY ; Tumors ; Uterine Cervical Neoplasms - mortality ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - radiotherapy ; UTERUS</subject><ispartof>International journal of radiation oncology, biology, physics, 1989-11, Vol.17 (5), p.973-978</ispartof><rights>1989</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-23571e700930e4d828f2f5fd66903889226d370445d82ab94e9f68015bae3c233</citedby><cites>FETCH-LOGICAL-c480t-23571e700930e4d828f2f5fd66903889226d370445d82ab94e9f68015bae3c233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0360-3016(89)90144-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19660406$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2808059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5100381$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Robert Y.</creatorcontrib><creatorcontrib>Trotti, Andy</creatorcontrib><creatorcontrib>Wu, Ching-Jung</creatorcontrib><creatorcontrib>Soong, S.J.</creatorcontrib><creatorcontrib>Salter, Merle M.</creatorcontrib><title>Radiation alone in the treatment of cancer of the uterine cervix: Analysis of pelvic failure and dose response relationship</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>This retrospective analysis involves 569 patients with invasive cancer of the uterine cervix treated with irradiation alone between 1969 and 1980. Treatment consisted of external and intracavitary irradiation and treatment policy remained consistant throughout the study interval. In early stage disease (FIGO IA, III, and IIA), pelvic failure was 4.6%, 11.2%, and 8.2%, respectively. In late stage disease (FIGO IIB, III, and IVA), pelvic failure was 30.1%, 52.3%, and 69.2%, respectively. Further analysis revealed that total dose at point A is well correlated with pelvic control. An aggressive treatment is crucial in late stage disease in determining the probability of pelvic tumor control and survival. Methods of dose prescription, dose-response relationships, treatment philosophy and its therapeutic implications are discussed.</description><subject>550603 - Medicine- External Radiation in Therapy- (1980-)</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - radiotherapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>BODY</subject><subject>Carcinoma of the cervix</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>DISEASES</subject><subject>Dose-Response Relationship, Radiation</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>DOSES</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>FEMALE GENITALS</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>NEOPLASMS</subject><subject>NUCLEAR MEDICINE</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>Pelvic failure</subject><subject>Pelvic Neoplasms - secondary</subject><subject>RADIATION DOSES</subject><subject>Radiation treatment</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Retrospective Studies</subject><subject>SURVIVAL CURVES</subject><subject>THERAPY</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - mortality</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><subject>UTERUS</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1rFDEUhoNY6lr9BwpBEPRi9GSSmUl6IZSirVAQRMG7kE1O2MhsZkiyi8U_b2Z3qXe9yiHvxzk8hLxi8IEB6z8C76HhdXon1XsFTIimfUJWTA6q4V336ylZPViekec5_wYAxgZxTs5bCRI6tSJ_vxsXTAlTpGacItIQadkgLQlN2WIsdPLUmmgxLdMi7QqmUJ31ax_-XNKraMb7HPKizzjug6XehHGXkJroqJsy0oR5nuJhGA_b8ibML8iZN2PGl6f3gvz88vnH9W1z9-3m6_XVXWOFhNK0vBsYDgCKAwonW-lb33nX9wq4lKpte8cHEKKrmlkrgcr3Eli3Nshty_kFeXPsnXIJOttQ0G7sFCPaojsGtYVVkziabJpyTuj1nMLWpHvNQC-89QJTLzC1VPrAW7c19voYm3frLbqH0Alw1d-edJOtGX2qKEP-3636HgT01ffp6MMKYh8wLXdixe5CWs50U3j8kH9KsZvj</recordid><startdate>19891101</startdate><enddate>19891101</enddate><creator>Kim, Robert Y.</creator><creator>Trotti, Andy</creator><creator>Wu, Ching-Jung</creator><creator>Soong, S.J.</creator><creator>Salter, Merle M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19891101</creationdate><title>Radiation alone in the treatment of cancer of the uterine cervix: Analysis of pelvic failure and dose response relationship</title><author>Kim, Robert Y. ; Trotti, Andy ; Wu, Ching-Jung ; Soong, S.J. ; Salter, Merle M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-23571e700930e4d828f2f5fd66903889226d370445d82ab94e9f68015bae3c233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>550603 - Medicine- External Radiation in Therapy- (1980-)</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - radiotherapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>BODY</topic><topic>Carcinoma of the cervix</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>DISEASES</topic><topic>Dose-Response Relationship, Radiation</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>DOSES</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>FEMALE GENITALS</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>NEOPLASMS</topic><topic>NUCLEAR MEDICINE</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>Pelvic failure</topic><topic>Pelvic Neoplasms - secondary</topic><topic>RADIATION DOSES</topic><topic>Radiation treatment</topic><topic>RADIOLOGY</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>Retrospective Studies</topic><topic>SURVIVAL CURVES</topic><topic>THERAPY</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - mortality</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><topic>UTERUS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Robert Y.</creatorcontrib><creatorcontrib>Trotti, Andy</creatorcontrib><creatorcontrib>Wu, Ching-Jung</creatorcontrib><creatorcontrib>Soong, S.J.</creatorcontrib><creatorcontrib>Salter, Merle M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Robert Y.</au><au>Trotti, Andy</au><au>Wu, Ching-Jung</au><au>Soong, S.J.</au><au>Salter, Merle M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiation alone in the treatment of cancer of the uterine cervix: Analysis of pelvic failure and dose response relationship</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1989-11-01</date><risdate>1989</risdate><volume>17</volume><issue>5</issue><spage>973</spage><epage>978</epage><pages>973-978</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>This retrospective analysis involves 569 patients with invasive cancer of the uterine cervix treated with irradiation alone between 1969 and 1980. Treatment consisted of external and intracavitary irradiation and treatment policy remained consistant throughout the study interval. In early stage disease (FIGO IA, III, and IIA), pelvic failure was 4.6%, 11.2%, and 8.2%, respectively. In late stage disease (FIGO IIB, III, and IVA), pelvic failure was 30.1%, 52.3%, and 69.2%, respectively. Further analysis revealed that total dose at point A is well correlated with pelvic control. An aggressive treatment is crucial in late stage disease in determining the probability of pelvic tumor control and survival. Methods of dose prescription, dose-response relationships, treatment philosophy and its therapeutic implications are discussed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2808059</pmid><doi>10.1016/0360-3016(89)90144-2</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of radiation oncology, biology, physics, 1989-11, Vol.17 (5), p.973-978 |
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| subjects | 550603 - Medicine- External Radiation in Therapy- (1980-) Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - radiotherapy Adult Aged Biological and medical sciences BODY Carcinoma of the cervix Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy DISEASES Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS DOSES Female Female genital diseases FEMALE GENITALS Gynecology. Andrology. Obstetrics Humans Medical sciences MEDICINE Middle Aged Neoplasm Staging NEOPLASMS NUCLEAR MEDICINE ORGANS PATIENTS Pelvic failure Pelvic Neoplasms - secondary RADIATION DOSES Radiation treatment RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Retrospective Studies SURVIVAL CURVES THERAPY Tumors Uterine Cervical Neoplasms - mortality Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy UTERUS |
| title | Radiation alone in the treatment of cancer of the uterine cervix: Analysis of pelvic failure and dose response relationship |
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