Importance of sulfation of gastrin or cholecystokinin (CCK) on affinity for gastrin and CCK receptors

We investigated the importance of sulfation of gastrin or cholecystokinin (CCK) on influencing their affinity for gastrin or CCK receptors by comparing the abilities of sulfated gastrin-17 (gastrin-17-II), desulfated gastrin-17 (gastrin-17-I), CCK-8 and desulfated CCK-8 [des(SO 3)CCK-8] to interact...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1989-07, Vol.10 (4), p.785-789
Hauptverfasser:	Huang, S.C, Yu, D.-H, Wank, S.A, Mantey, S, Gardner, J.D, Jensen, R.T
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques AFFINITY AMYLASE Amylases - metabolism ANIMALS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BIOCHEMICAL REACTION KINETICS Biological and medical sciences BODY Cholecystokinin - metabolism DAYS LIVING RADIOISOTOPES DIGESTIVE SYSTEM ELECTRON CAPTURE RADIOISOTOPES ENDOCRINE GLANDS Endocrine pancreas ENZYMES Fundamental and applied biological sciences. Psychology GASTRIN Gastrins - metabolism GLANDS GLYCOSYL HYDROLASES GUINEA PIGS HORMONES Hormones. Régulation HYDROLASES IN VITRO In Vitro Techniques INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES Iodine Radioisotopes ISOTOPE APPLICATIONS ISOTOPES KINETICS KININS Male MAMMALS MEMBRANE PROTEINS NUCLEI O-GLYCOSYL HYDROLASES ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANS OXYGEN COMPOUNDS PANCREAS Pancreas - enzymology Pancreas - metabolism Pancreatic acini PEPTIDE HORMONES PEPTIDES POLYPEPTIDES PROTEINS RADIOISOTOPES REACTION KINETICS Receptor affinity RECEPTORS Receptors, Cholecystokinin - metabolism RODENTS Sincalide - analogs & derivatives Sincalide - metabolism Succinimides - metabolism SULFATES Sulfates - metabolism Sulfation SULFUR COMPOUNDS TRACER TECHNIQUES VERTEBRATES Vertebrates: endocrinology
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