Lymphatic and hematopoietic tissue cancer in a chemical manufacturing environment
Nested case‐control studies of non‐Hodgkin's lymphoma (52 cases), multiple myeloma (20 cases), nonlymphocytic leukemia (39 cases), and lymphocytic leukemia (18 cases) were conducted within a cohort of employed men from two chemical manufacturing facilities and a research and development center....
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| Veröffentlicht in: | American journal of industrial medicine 1989, Vol.16 (6), p.631-643 |
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| creator | Ott, M. Gerald Teta, M. Jane Greenberg, Howard L. |
| description | Nested case‐control studies of non‐Hodgkin's lymphoma (52 cases), multiple myeloma (20 cases), nonlymphocytic leukemia (39 cases), and lymphocytic leukemia (18 cases) were conducted within a cohort of employed men from two chemical manufacturing facilities and a research and development center. Exposure odds ratios were examined in relation to 111 work areas, 21 specific chemicals, and 52 chemical activity groups. Associations were observed for a maintenance and construction subgroup (non‐Hodgkin's lymphoma) and a chlorohydrin production unit (nonlymphocytic leukemia). The odds ratio for the association of “foremen and others” with non‐Hodgkin's lymphoma was 3.2 (CI95 = 1.47–7.2) based on 11 cases. A duration‐response trend was observed for the chlorohydrin unit with three of four cases assigned 5 + years to that unit. An association between non‐Hodgkin's lymphoma and assignment to strong acid alcohol production units (OR = 8.3; CI95 = 2.3–30.7) was not supported by a duration‐response trend. Two highly correlated chemical groups, antioxidants (five cases) and nitriles (four cases), were over‐represented among multiple myeloma cases. A duration effect was observed. However, examination of work histories did not reveal common jobs or departments among these cases. |
| doi_str_mv | 10.1002/ajim.4700160603 |
| format | Article |
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Gerald ; Teta, M. Jane ; Greenberg, Howard L.</creator><creatorcontrib>Ott, M. Gerald ; Teta, M. Jane ; Greenberg, Howard L.</creatorcontrib><description>Nested case‐control studies of non‐Hodgkin's lymphoma (52 cases), multiple myeloma (20 cases), nonlymphocytic leukemia (39 cases), and lymphocytic leukemia (18 cases) were conducted within a cohort of employed men from two chemical manufacturing facilities and a research and development center. Exposure odds ratios were examined in relation to 111 work areas, 21 specific chemicals, and 52 chemical activity groups. Associations were observed for a maintenance and construction subgroup (non‐Hodgkin's lymphoma) and a chlorohydrin production unit (nonlymphocytic leukemia). The odds ratio for the association of “foremen and others” with non‐Hodgkin's lymphoma was 3.2 (CI95 = 1.47–7.2) based on 11 cases. A duration‐response trend was observed for the chlorohydrin unit with three of four cases assigned 5 + years to that unit. An association between non‐Hodgkin's lymphoma and assignment to strong acid alcohol production units (OR = 8.3; CI95 = 2.3–30.7) was not supported by a duration‐response trend. Two highly correlated chemical groups, antioxidants (five cases) and nitriles (four cases), were over‐represented among multiple myeloma cases. A duration effect was observed. However, examination of work histories did not reveal common jobs or departments among these cases.</description><identifier>ISSN: 0271-3586</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.4700160603</identifier><identifier>PMID: 2556914</identifier><identifier>CODEN: AJIMD8</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; Aged ; Alkanesulfonates - adverse effects ; alkyl sulfates ; ANTIOXIDANTS ; Biological and medical sciences ; CARCINOGENESIS ; CHEMICAL INDUSTRY ; DISEASES ; EPIDEMIOLOGY ; ethylene chlorohydrin ; Ethylene Chlorohydrin - adverse effects ; FEDERAL REGION III ; Follow-Up Studies ; HAZARDS ; HEALTH HAZARDS ; Hematologic and hematopoietic diseases ; HEMIC DISEASES ; Humans ; IMMUNE SYSTEM DISEASES ; INDUSTRY ; LEUKEMIA ; Leukemia, Lymphoid - chemically induced ; Leukemia, Lymphoid - mortality ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; lymphoma ; Lymphoma, Non-Hodgkin - chemically induced ; Lymphoma, Non-Hodgkin - mortality ; LYMPHOMAS ; Male ; Medical sciences ; Middle Aged ; multiple myeloma ; Multiple Myeloma - chemically induced ; Multiple Myeloma - mortality ; NEOPLASMS ; NITRILES ; NORTH AMERICA ; OCCUPATIONAL DISEASES ; Occupational Diseases - chemically induced ; Occupational Diseases - mortality ; occupational epidemiology ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; PATHOGENESIS ; PERSONNEL ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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Gerald</creatorcontrib><creatorcontrib>Teta, M. Jane</creatorcontrib><creatorcontrib>Greenberg, Howard L.</creatorcontrib><title>Lymphatic and hematopoietic tissue cancer in a chemical manufacturing environment</title><title>American journal of industrial medicine</title><addtitle>Am. J. Ind. Med</addtitle><description>Nested case‐control studies of non‐Hodgkin's lymphoma (52 cases), multiple myeloma (20 cases), nonlymphocytic leukemia (39 cases), and lymphocytic leukemia (18 cases) were conducted within a cohort of employed men from two chemical manufacturing facilities and a research and development center. Exposure odds ratios were examined in relation to 111 work areas, 21 specific chemicals, and 52 chemical activity groups. Associations were observed for a maintenance and construction subgroup (non‐Hodgkin's lymphoma) and a chlorohydrin production unit (nonlymphocytic leukemia). The odds ratio for the association of “foremen and others” with non‐Hodgkin's lymphoma was 3.2 (CI95 = 1.47–7.2) based on 11 cases. A duration‐response trend was observed for the chlorohydrin unit with three of four cases assigned 5 + years to that unit. An association between non‐Hodgkin's lymphoma and assignment to strong acid alcohol production units (OR = 8.3; CI95 = 2.3–30.7) was not supported by a duration‐response trend. Two highly correlated chemical groups, antioxidants (five cases) and nitriles (four cases), were over‐represented among multiple myeloma cases. A duration effect was observed. However, examination of work histories did not reveal common jobs or departments among these cases.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>Aged</subject><subject>Alkanesulfonates - adverse effects</subject><subject>alkyl sulfates</subject><subject>ANTIOXIDANTS</subject><subject>Biological and medical sciences</subject><subject>CARCINOGENESIS</subject><subject>CHEMICAL INDUSTRY</subject><subject>DISEASES</subject><subject>EPIDEMIOLOGY</subject><subject>ethylene chlorohydrin</subject><subject>Ethylene Chlorohydrin - adverse effects</subject><subject>FEDERAL REGION III</subject><subject>Follow-Up Studies</subject><subject>HAZARDS</subject><subject>HEALTH HAZARDS</subject><subject>Hematologic and hematopoietic diseases</subject><subject>HEMIC DISEASES</subject><subject>Humans</subject><subject>IMMUNE SYSTEM DISEASES</subject><subject>INDUSTRY</subject><subject>LEUKEMIA</subject><subject>Leukemia, Lymphoid - chemically induced</subject><subject>Leukemia, Lymphoid - mortality</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>lymphoma</subject><subject>Lymphoma, Non-Hodgkin - chemically induced</subject><subject>Lymphoma, Non-Hodgkin - mortality</subject><subject>LYMPHOMAS</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>multiple myeloma</subject><subject>Multiple Myeloma - chemically induced</subject><subject>Multiple Myeloma - mortality</subject><subject>NEOPLASMS</subject><subject>NITRILES</subject><subject>NORTH AMERICA</subject><subject>OCCUPATIONAL DISEASES</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational Diseases - mortality</subject><subject>occupational epidemiology</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>PATHOGENESIS</subject><subject>PERSONNEL</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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Jane ; Greenberg, Howard L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5333-9dc0b8350ae984dedd1d2b71d4d7c87ca9490adebf72ff20f07fb71b20b0a4fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>Aged</topic><topic>Alkanesulfonates - adverse effects</topic><topic>alkyl sulfates</topic><topic>ANTIOXIDANTS</topic><topic>Biological and medical sciences</topic><topic>CARCINOGENESIS</topic><topic>CHEMICAL INDUSTRY</topic><topic>DISEASES</topic><topic>EPIDEMIOLOGY</topic><topic>ethylene chlorohydrin</topic><topic>Ethylene Chlorohydrin - adverse effects</topic><topic>FEDERAL REGION III</topic><topic>Follow-Up Studies</topic><topic>HAZARDS</topic><topic>HEALTH HAZARDS</topic><topic>Hematologic and hematopoietic diseases</topic><topic>HEMIC DISEASES</topic><topic>Humans</topic><topic>IMMUNE SYSTEM DISEASES</topic><topic>INDUSTRY</topic><topic>LEUKEMIA</topic><topic>Leukemia, Lymphoid - chemically induced</topic><topic>Leukemia, Lymphoid - mortality</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>lymphoma</topic><topic>Lymphoma, Non-Hodgkin - chemically induced</topic><topic>Lymphoma, Non-Hodgkin - mortality</topic><topic>LYMPHOMAS</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>multiple myeloma</topic><topic>Multiple Myeloma - chemically induced</topic><topic>Multiple Myeloma - mortality</topic><topic>NEOPLASMS</topic><topic>NITRILES</topic><topic>NORTH AMERICA</topic><topic>OCCUPATIONAL DISEASES</topic><topic>Occupational Diseases - chemically induced</topic><topic>Occupational Diseases - mortality</topic><topic>occupational epidemiology</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>PATHOGENESIS</topic><topic>PERSONNEL</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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Gerald</au><au>Teta, M. Jane</au><au>Greenberg, Howard L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphatic and hematopoietic tissue cancer in a chemical manufacturing environment</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am. J. Ind. Med</addtitle><date>1989</date><risdate>1989</risdate><volume>16</volume><issue>6</issue><spage>631</spage><epage>643</epage><pages>631-643</pages><issn>0271-3586</issn><eissn>1097-0274</eissn><coden>AJIMD8</coden><abstract>Nested case‐control studies of non‐Hodgkin's lymphoma (52 cases), multiple myeloma (20 cases), nonlymphocytic leukemia (39 cases), and lymphocytic leukemia (18 cases) were conducted within a cohort of employed men from two chemical manufacturing facilities and a research and development center. Exposure odds ratios were examined in relation to 111 work areas, 21 specific chemicals, and 52 chemical activity groups. Associations were observed for a maintenance and construction subgroup (non‐Hodgkin's lymphoma) and a chlorohydrin production unit (nonlymphocytic leukemia). The odds ratio for the association of “foremen and others” with non‐Hodgkin's lymphoma was 3.2 (CI95 = 1.47–7.2) based on 11 cases. A duration‐response trend was observed for the chlorohydrin unit with three of four cases assigned 5 + years to that unit. An association between non‐Hodgkin's lymphoma and assignment to strong acid alcohol production units (OR = 8.3; CI95 = 2.3–30.7) was not supported by a duration‐response trend. Two highly correlated chemical groups, antioxidants (five cases) and nitriles (four cases), were over‐represented among multiple myeloma cases. A duration effect was observed. However, examination of work histories did not reveal common jobs or departments among these cases.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2556914</pmid><doi>10.1002/ajim.4700160603</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-3586 |
| ispartof | American journal of industrial medicine, 1989, Vol.16 (6), p.631-643 |
| issn | 0271-3586 1097-0274 |
| language | eng |
| recordid | cdi_osti_scitechconnect_5043335 |
| source | MEDLINE; Wiley Journals |
| subjects | 560300 - Chemicals Metabolism & Toxicology Aged Alkanesulfonates - adverse effects alkyl sulfates ANTIOXIDANTS Biological and medical sciences CARCINOGENESIS CHEMICAL INDUSTRY DISEASES EPIDEMIOLOGY ethylene chlorohydrin Ethylene Chlorohydrin - adverse effects FEDERAL REGION III Follow-Up Studies HAZARDS HEALTH HAZARDS Hematologic and hematopoietic diseases HEMIC DISEASES Humans IMMUNE SYSTEM DISEASES INDUSTRY LEUKEMIA Leukemia, Lymphoid - chemically induced Leukemia, Lymphoid - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis lymphoma Lymphoma, Non-Hodgkin - chemically induced Lymphoma, Non-Hodgkin - mortality LYMPHOMAS Male Medical sciences Middle Aged multiple myeloma Multiple Myeloma - chemically induced Multiple Myeloma - mortality NEOPLASMS NITRILES NORTH AMERICA OCCUPATIONAL DISEASES Occupational Diseases - chemically induced Occupational Diseases - mortality occupational epidemiology ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS PATHOGENESIS PERSONNEL RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT USA WEST VIRGINIA West Virginia - epidemiology |
| title | Lymphatic and hematopoietic tissue cancer in a chemical manufacturing environment |
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