Novel inhibitors of human leukocyte elastase and cathepsin G. Sequence variants of squash seed protease inhibitor with altered protease selectivity

Novel peptide inhibitors of human leukocyte elastase (HLE) and cathepsin G (CG) were prepared by solid-phase peptide synthesis of P1 amino acid sequence variants of Curcurbita maxima trypsin inhibitor III (CMTI-III), a 29-residue peptide found in squash seed. A systematic study of P1 variants indica...

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Veröffentlicht in:	Biochemistry (Easton) 1989-07, Vol.28 (14), p.5708-5714
Hauptverfasser:	McWherter, Charles A, Walkenhorst, William F, Campbell, Edward J, Glover, George I
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques AMINO ACID SEQUENCE Analytical, structural and metabolic biochemistry ANIMALS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES Binding Sites BIOCHEMISTRY Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BLOOD COAGULATION FACTORS BODY FLUIDS catalytic activity Cathepsin G CATHEPSINS Cathepsins - antagonists & inhibitors CHEMICAL REACTIONS CHEMISTRY COAGULANTS Cucurbita maxima Curcubita maxima DAYS LIVING RADIOISOTOPES DECOMPOSITION DRUGS elastase ELECTRON CAPTURE RADIOISOTOPES ENZYMATIC HYDROLYSIS ENZYME INHIBITORS ENZYMES Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Genetic Variation HEMATOLOGIC AGENTS Humans HYDROLASES HYDROLYSIS In Vitro Techniques INFLAMMATION INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES ISOTOPES Kinetics LEUKOCYTES Leukocytes - enzymology LYSIS MAMMALS MAN MATERIALS MOLECULAR STRUCTURE NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS Pancreatic Elastase - antagonists & inhibitors Pancreatic Elastase - blood PATHOLOGICAL CHANGES PEPTIDE HYDROLASES PRIMATES Protease Inhibitors - genetics Protease Inhibitors - pharmacology proteinase inhibitors PROTEINS RADIOISOTOPES seeds Seeds - analysis Serine Endopeptidases SERINE PROTEINASES SH-PROTEINASES SOLVOLYSIS SYMPTOMS TRYPSIN VERTEBRATES
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