Formation of 8-hydroxy(deoxy)guanosine and generation of strand breaks at guanine residues in DNA by singlet oxygen

Singlet molecular oxygen (1O2) was generated in aqueous solution (H2O or D2O) at 37 degrees C by the thermal dissociation of the endoperoxide of 3,3'-(1,4-naphthylidene) dipropionate (NDPO2). Guanosine and deoxyguanosine quench 1O2 with overall quenching rate constants of 6.2 X 10(6) M-1 s-1 an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 1991-06, Vol.30 (25), p.6283-6289
Hauptverfasser:	Devasagayam, Thomas P. A, Steenken, Steen, Obendorf, Maik S. W, Schulz, Wolfgang A, Sies, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics AMINES AQUEOUS SOLUTIONS AROMATICS AUTORADIOGRAPHY AZAARENES Azides - pharmacology Biological and medical sciences BIOLOGICAL EFFECTS CELL CONSTITUENTS Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism DISPERSIONS DNA DNA - drug effects DNA Damage ELEMENTS Free Radical Scavengers Fundamental and applied biological sciences. Psychology GUANINE HEAVY WATER HETEROCYCLIC COMPOUNDS HYDROGEN COMPOUNDS Hydroxides - metabolism HYDROXY COMPOUNDS METALLOPROTEINS METALLOTHIONEIN MIXTURES Molecular and cellular biology Molecular genetics Mutagenesis. Repair NONMETALS NUCLEIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC SULFUR COMPOUNDS OXYGEN Oxygen - pharmacology OXYGEN COMPOUNDS PEROXIDES PLASMIDS PROTEINS PURINES RADIOLOGY AND NUCLEAR MEDICINE Singlet Oxygen Sodium Azide SOLUTIONS STRAND BREAKS Sulfhydryl Compounds - pharmacology THIOLS WATER
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!