Early effects of uranyl nitrate on respiration and K sup + transport in rabbit proximal tubule

The mechanisms by which uranyl nitrate (UN) is toxic to the proximal tubule are incompletely understood. To define these further we studied potassium (K+) transport and oxygen consumption (QO2) in rabbit proximal tubule suspensions in vitro immediately after exposure to UN using extracellular O2- an...

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Veröffentlicht in:	Kidney international 1989-07, Vol.36:1
Hauptverfasser:	Brady, H.R., Kone, B.C., Brenner, R.M., Gullans, S.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells ACID ANHYDRASES ACTINIDE COMPOUNDS ALKALI METAL COMPOUNDS ANIMALS ATP ATP-ASE BODY CARBOHYDRATES CARDIAC GLYCOSIDES CARDIOTONICS CARDIOVASCULAR AGENTS CELL CONSTITUENTS DOSE-RESPONSE RELATIONSHIPS DRUGS ELEMENTS ENZYME ACTIVITY ENZYMES GLUTATHIONE GLYCOSIDES HYDROLASES IN VITRO KIDNEYS MAMMALS MEMBRANE TRANSPORT MITOCHONDRIA NITRATES NITROGEN COMPOUNDS NONMETALS NUCLEOTIDES ORGANIC COMPOUNDS ORGANOIDS ORGANS OUABAIN OXYGEN OXYGEN COMPOUNDS PEPTIDES PERMEABILITY PHOSPHOHYDROLASES POLYPEPTIDES POTASSIUM COMPOUNDS PROTEINS RABBITS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIONUCLIDE KINETICS RADIOPROTECTIVE SUBSTANCES RESPIRATION STROPHANTHINS TOXICITY TUBULES URANIUM COMPOUNDS URANYL COMPOUNDS URANYL NITRATES VERTEBRATES
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