Quantitation of cutaneous inflammation induced by reactive species generated by UV-visible irradiation of Rose Bengal
The present studies were undertaken to quantitate the initial inflammatory response produced by the photo-generated reactive species in rabbit skin. Rose bengal (RB), a photosensitizer dye, was injected into the skin sites at various concentrations and exposed to UV-visible light for 30-120 min. The...
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| Veröffentlicht in: | Inflammation 1989-10, Vol.13 (5), p.483-494 |
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| creator | RANADIVE, N. S ARAVIND MENON, I SHIRWADKAR, S PERSAD, S. D |
| description | The present studies were undertaken to quantitate the initial inflammatory response produced by the photo-generated reactive species in rabbit skin. Rose bengal (RB), a photosensitizer dye, was injected into the skin sites at various concentrations and exposed to UV-visible light for 30-120 min. The increase in vascular permeability and the accumulation of PMNs were investigated using 125I-labeled albumin and 51Cr-labeled PMNs. RB at a concentration of 1 nmol with 120-min exposure to light enhanced vascular permeability by 3.7 times and accumulation of PMNs by 3.3 times. As low as 0.01 nmol of RB produced discernible effects. beta-Carotene (0.1 nmole) inhibited the inflammatory response by 75-100%, suggesting that the reactive species involved in this response was predominantly singlet oxygen. The increase in vascular permeability was inhibited by 48-70% by 25 micrograms of chlorpheniramine maleate. It is therefore suggested that histamine plays a major role in the initial vascular response. The studies demonstrate that this rabbit model is suitable for the quantitation of photoinduced inflammatory response which is not observable by gross anatomic procedures. |
| doi_str_mv | 10.1007/BF00916756 |
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S ; ARAVIND MENON, I ; SHIRWADKAR, S ; PERSAD, S. D</creator><creatorcontrib>RANADIVE, N. S ; ARAVIND MENON, I ; SHIRWADKAR, S ; PERSAD, S. D</creatorcontrib><description>The present studies were undertaken to quantitate the initial inflammatory response produced by the photo-generated reactive species in rabbit skin. Rose bengal (RB), a photosensitizer dye, was injected into the skin sites at various concentrations and exposed to UV-visible light for 30-120 min. The increase in vascular permeability and the accumulation of PMNs were investigated using 125I-labeled albumin and 51Cr-labeled PMNs. RB at a concentration of 1 nmol with 120-min exposure to light enhanced vascular permeability by 3.7 times and accumulation of PMNs by 3.3 times. As low as 0.01 nmol of RB produced discernible effects. beta-Carotene (0.1 nmole) inhibited the inflammatory response by 75-100%, suggesting that the reactive species involved in this response was predominantly singlet oxygen. The increase in vascular permeability was inhibited by 48-70% by 25 micrograms of chlorpheniramine maleate. It is therefore suggested that histamine plays a major role in the initial vascular response. The studies demonstrate that this rabbit model is suitable for the quantitation of photoinduced inflammatory response which is not observable by gross anatomic procedures.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/BF00916756</identifier><identifier>PMID: 2478468</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>550901 - Pathology- Tracer Techniques ; AMINES ; ANIMALS ; AZOLES ; BASIC BIOLOGICAL SCIENCES ; beta Carotene ; BETA DECAY RADIOISOTOPES ; BIOLOGICAL ACCUMULATION ; Biological and medical sciences ; Biological effects of radiation ; BIOLOGICAL MATERIALS ; BLOOD ; BLOOD CELLS ; BLOOD VESSELS ; BODY ; BODY FLUIDS ; CAPILLARIES ; Capillary Permeability ; CARBOXYLIC ACIDS ; CARDIOVASCULAR SYSTEM ; Carotenoids - pharmacology ; Chlorpheniramine - pharmacology ; CHROMIUM 51 ; CHROMIUM ISOTOPES ; Disease Models, Animal ; DISEASES ; DRUGS ; DYES ; ELECTROMAGNETIC RADIATION ; ELECTRON CAPTURE RADIOISOTOPES ; ELEMENTS ; EVEN-ODD NUCLEI ; Free Radicals ; Fundamental and applied biological sciences. Psychology ; HETEROCYCLIC COMPOUNDS ; HISTAMINE ; Histamine Release - drug effects ; HYDROXY ACIDS ; IMIDAZOLES ; INDICATORS ; INTERMEDIATE MASS NUCLEI ; ISOTOPE APPLICATIONS ; ISOTOPES ; LEUKOCYTES ; MAMMALS ; MATERIALS ; NEUTROPHILS ; Neutrophils - pathology ; NONMETALS ; NUCLEI ; ORGANIC ACIDS ; ORGANIC CHLORINE COMPOUNDS ; ORGANIC COMPOUNDS ; ORGANIC HALOGEN COMPOUNDS ; ORGANIC IODINE COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANS ; OXYGEN ; Oxygen - toxicity ; PERMEABILITY ; Photosensitivity Disorders - chemically induced ; Photosensitivity Disorders - pathology ; RABBITS ; RADIATIONS ; RADICALS ; RADIOINDUCTION ; RADIOISOTOPES ; RADIOSENSITIZERS ; Radiosensitizing agents. Photosensitizing agents. Thermosensitizing agents ; REAGENTS ; ROSE BENGAL ; Rose Bengal - radiation effects ; Rose Bengal - toxicity ; Singlet Oxygen ; SKIN ; Skin - blood supply ; SKIN DISEASES ; Tissues, organs and organisms biophysics ; TRACER TECHNIQUES ; ULTRAVIOLET RADIATION ; Ultraviolet Rays ; VERTEBRATES</subject><ispartof>Inflammation, 1989-10, Vol.13 (5), p.483-494</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-dcbdcb72342c52f04b19fe3630628e910e779a289e7d9d485dc32657506f3e213</citedby><cites>FETCH-LOGICAL-c369t-dcbdcb72342c52f04b19fe3630628e910e779a289e7d9d485dc32657506f3e213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6641499$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2478468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5023628$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>RANADIVE, N. S</creatorcontrib><creatorcontrib>ARAVIND MENON, I</creatorcontrib><creatorcontrib>SHIRWADKAR, S</creatorcontrib><creatorcontrib>PERSAD, S. D</creatorcontrib><title>Quantitation of cutaneous inflammation induced by reactive species generated by UV-visible irradiation of Rose Bengal</title><title>Inflammation</title><addtitle>Inflammation</addtitle><description>The present studies were undertaken to quantitate the initial inflammatory response produced by the photo-generated reactive species in rabbit skin. Rose bengal (RB), a photosensitizer dye, was injected into the skin sites at various concentrations and exposed to UV-visible light for 30-120 min. The increase in vascular permeability and the accumulation of PMNs were investigated using 125I-labeled albumin and 51Cr-labeled PMNs. RB at a concentration of 1 nmol with 120-min exposure to light enhanced vascular permeability by 3.7 times and accumulation of PMNs by 3.3 times. As low as 0.01 nmol of RB produced discernible effects. beta-Carotene (0.1 nmole) inhibited the inflammatory response by 75-100%, suggesting that the reactive species involved in this response was predominantly singlet oxygen. The increase in vascular permeability was inhibited by 48-70% by 25 micrograms of chlorpheniramine maleate. It is therefore suggested that histamine plays a major role in the initial vascular response. The studies demonstrate that this rabbit model is suitable for the quantitation of photoinduced inflammatory response which is not observable by gross anatomic procedures.</description><subject>550901 - Pathology- Tracer Techniques</subject><subject>AMINES</subject><subject>ANIMALS</subject><subject>AZOLES</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>beta Carotene</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BIOLOGICAL ACCUMULATION</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>BLOOD VESSELS</subject><subject>BODY</subject><subject>BODY FLUIDS</subject><subject>CAPILLARIES</subject><subject>Capillary Permeability</subject><subject>CARBOXYLIC ACIDS</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>Carotenoids - pharmacology</subject><subject>Chlorpheniramine - pharmacology</subject><subject>CHROMIUM 51</subject><subject>CHROMIUM ISOTOPES</subject><subject>Disease Models, Animal</subject><subject>DISEASES</subject><subject>DRUGS</subject><subject>DYES</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>ELEMENTS</subject><subject>EVEN-ODD NUCLEI</subject><subject>Free Radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HISTAMINE</subject><subject>Histamine Release - drug effects</subject><subject>HYDROXY ACIDS</subject><subject>IMIDAZOLES</subject><subject>INDICATORS</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>ISOTOPE APPLICATIONS</subject><subject>ISOTOPES</subject><subject>LEUKOCYTES</subject><subject>MAMMALS</subject><subject>MATERIALS</subject><subject>NEUTROPHILS</subject><subject>Neutrophils - pathology</subject><subject>NONMETALS</subject><subject>NUCLEI</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC CHLORINE COMPOUNDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC HALOGEN COMPOUNDS</subject><subject>ORGANIC IODINE COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>OXYGEN</subject><subject>Oxygen - toxicity</subject><subject>PERMEABILITY</subject><subject>Photosensitivity Disorders - chemically induced</subject><subject>Photosensitivity Disorders - pathology</subject><subject>RABBITS</subject><subject>RADIATIONS</subject><subject>RADICALS</subject><subject>RADIOINDUCTION</subject><subject>RADIOISOTOPES</subject><subject>RADIOSENSITIZERS</subject><subject>Radiosensitizing agents. Photosensitizing agents. Thermosensitizing agents</subject><subject>REAGENTS</subject><subject>ROSE BENGAL</subject><subject>Rose Bengal - radiation effects</subject><subject>Rose Bengal - toxicity</subject><subject>Singlet Oxygen</subject><subject>SKIN</subject><subject>Skin - blood supply</subject><subject>SKIN DISEASES</subject><subject>Tissues, organs and organisms biophysics</subject><subject>TRACER TECHNIQUES</subject><subject>ULTRAVIOLET RADIATION</subject><subject>Ultraviolet Rays</subject><subject>VERTEBRATES</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtLxDAUhYMoOj427oUg4kKo5tEkzdIRXyCI4rgtaXqrkTYdk1SYf2-lwwgX7uL7OItzEDqm5JISoq7md4RoKpWQW2hGheIZE0puoxnhkmRca7WH9mP8IoQUuuC7aJflqshlMUPDy2B8cskk13vcN9gOyXjoh4idb1rTdRNxvh4s1Lha4QDGJvcDOC7BOoj4AzwEkya6eM9-XHRVC9iFYGq3SX7tI-A5-A_THqKdxrQRjtb_AC3ubt9uHrKn5_vHm-unzHKpU1bbajzFeM6sYA3JK6ob4JITyQrQlIBS2rBCg6p1nReitpxJoQSRDQdG-QE6nXL7mFwZrUtgP23vPdhUCsL4mDNK55O0DP33ADGVnYsW2nbqoaQil5wyPooXk2hDH2OAplwG15mwKikp_4Yo_4cY5ZN16lB1UG_UdfMjP1tzE61pm2C8dXGjSZnTXGv-C28Vj-I</recordid><startdate>19891001</startdate><enddate>19891001</enddate><creator>RANADIVE, N. S</creator><creator>ARAVIND MENON, I</creator><creator>SHIRWADKAR, S</creator><creator>PERSAD, S. D</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>OTOTI</scope></search><sort><creationdate>19891001</creationdate><title>Quantitation of cutaneous inflammation induced by reactive species generated by UV-visible irradiation of Rose Bengal</title><author>RANADIVE, N. S ; ARAVIND MENON, I ; SHIRWADKAR, S ; PERSAD, S. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-dcbdcb72342c52f04b19fe3630628e910e779a289e7d9d485dc32657506f3e213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>550901 - Pathology- Tracer Techniques</topic><topic>AMINES</topic><topic>ANIMALS</topic><topic>AZOLES</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>beta Carotene</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BIOLOGICAL ACCUMULATION</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BLOOD</topic><topic>BLOOD CELLS</topic><topic>BLOOD VESSELS</topic><topic>BODY</topic><topic>BODY FLUIDS</topic><topic>CAPILLARIES</topic><topic>Capillary Permeability</topic><topic>CARBOXYLIC ACIDS</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>Carotenoids - pharmacology</topic><topic>Chlorpheniramine - pharmacology</topic><topic>CHROMIUM 51</topic><topic>CHROMIUM ISOTOPES</topic><topic>Disease Models, Animal</topic><topic>DISEASES</topic><topic>DRUGS</topic><topic>DYES</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>ELEMENTS</topic><topic>EVEN-ODD NUCLEI</topic><topic>Free Radicals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HISTAMINE</topic><topic>Histamine Release - drug effects</topic><topic>HYDROXY ACIDS</topic><topic>IMIDAZOLES</topic><topic>INDICATORS</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>ISOTOPE APPLICATIONS</topic><topic>ISOTOPES</topic><topic>LEUKOCYTES</topic><topic>MAMMALS</topic><topic>MATERIALS</topic><topic>NEUTROPHILS</topic><topic>Neutrophils - pathology</topic><topic>NONMETALS</topic><topic>NUCLEI</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC CHLORINE COMPOUNDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC HALOGEN COMPOUNDS</topic><topic>ORGANIC IODINE COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>OXYGEN</topic><topic>Oxygen - toxicity</topic><topic>PERMEABILITY</topic><topic>Photosensitivity Disorders - chemically induced</topic><topic>Photosensitivity Disorders - pathology</topic><topic>RABBITS</topic><topic>RADIATIONS</topic><topic>RADICALS</topic><topic>RADIOINDUCTION</topic><topic>RADIOISOTOPES</topic><topic>RADIOSENSITIZERS</topic><topic>Radiosensitizing agents. Photosensitizing agents. Thermosensitizing agents</topic><topic>REAGENTS</topic><topic>ROSE BENGAL</topic><topic>Rose Bengal - radiation effects</topic><topic>Rose Bengal - toxicity</topic><topic>Singlet Oxygen</topic><topic>SKIN</topic><topic>Skin - blood supply</topic><topic>SKIN DISEASES</topic><topic>Tissues, organs and organisms biophysics</topic><topic>TRACER TECHNIQUES</topic><topic>ULTRAVIOLET RADIATION</topic><topic>Ultraviolet Rays</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RANADIVE, N. S</creatorcontrib><creatorcontrib>ARAVIND MENON, I</creatorcontrib><creatorcontrib>SHIRWADKAR, S</creatorcontrib><creatorcontrib>PERSAD, S. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RANADIVE, N. S</au><au>ARAVIND MENON, I</au><au>SHIRWADKAR, S</au><au>PERSAD, S. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitation of cutaneous inflammation induced by reactive species generated by UV-visible irradiation of Rose Bengal</atitle><jtitle>Inflammation</jtitle><addtitle>Inflammation</addtitle><date>1989-10-01</date><risdate>1989</risdate><volume>13</volume><issue>5</issue><spage>483</spage><epage>494</epage><pages>483-494</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><coden>INFLD4</coden><abstract>The present studies were undertaken to quantitate the initial inflammatory response produced by the photo-generated reactive species in rabbit skin. Rose bengal (RB), a photosensitizer dye, was injected into the skin sites at various concentrations and exposed to UV-visible light for 30-120 min. The increase in vascular permeability and the accumulation of PMNs were investigated using 125I-labeled albumin and 51Cr-labeled PMNs. RB at a concentration of 1 nmol with 120-min exposure to light enhanced vascular permeability by 3.7 times and accumulation of PMNs by 3.3 times. As low as 0.01 nmol of RB produced discernible effects. beta-Carotene (0.1 nmole) inhibited the inflammatory response by 75-100%, suggesting that the reactive species involved in this response was predominantly singlet oxygen. The increase in vascular permeability was inhibited by 48-70% by 25 micrograms of chlorpheniramine maleate. It is therefore suggested that histamine plays a major role in the initial vascular response. The studies demonstrate that this rabbit model is suitable for the quantitation of photoinduced inflammatory response which is not observable by gross anatomic procedures.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>2478468</pmid><doi>10.1007/BF00916756</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Inflammation, 1989-10, Vol.13 (5), p.483-494 |
| issn | 0360-3997 1573-2576 |
| language | eng |
| recordid | cdi_osti_scitechconnect_5023628 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 550901 - Pathology- Tracer Techniques AMINES ANIMALS AZOLES BASIC BIOLOGICAL SCIENCES beta Carotene BETA DECAY RADIOISOTOPES BIOLOGICAL ACCUMULATION Biological and medical sciences Biological effects of radiation BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BLOOD VESSELS BODY BODY FLUIDS CAPILLARIES Capillary Permeability CARBOXYLIC ACIDS CARDIOVASCULAR SYSTEM Carotenoids - pharmacology Chlorpheniramine - pharmacology CHROMIUM 51 CHROMIUM ISOTOPES Disease Models, Animal DISEASES DRUGS DYES ELECTROMAGNETIC RADIATION ELECTRON CAPTURE RADIOISOTOPES ELEMENTS EVEN-ODD NUCLEI Free Radicals Fundamental and applied biological sciences. Psychology HETEROCYCLIC COMPOUNDS HISTAMINE Histamine Release - drug effects HYDROXY ACIDS IMIDAZOLES INDICATORS INTERMEDIATE MASS NUCLEI ISOTOPE APPLICATIONS ISOTOPES LEUKOCYTES MAMMALS MATERIALS NEUTROPHILS Neutrophils - pathology NONMETALS NUCLEI ORGANIC ACIDS ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC IODINE COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS OXYGEN Oxygen - toxicity PERMEABILITY Photosensitivity Disorders - chemically induced Photosensitivity Disorders - pathology RABBITS RADIATIONS RADICALS RADIOINDUCTION RADIOISOTOPES RADIOSENSITIZERS Radiosensitizing agents. Photosensitizing agents. Thermosensitizing agents REAGENTS ROSE BENGAL Rose Bengal - radiation effects Rose Bengal - toxicity Singlet Oxygen SKIN Skin - blood supply SKIN DISEASES Tissues, organs and organisms biophysics TRACER TECHNIQUES ULTRAVIOLET RADIATION Ultraviolet Rays VERTEBRATES |
| title | Quantitation of cutaneous inflammation induced by reactive species generated by UV-visible irradiation of Rose Bengal |
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