Study of the mechanism of innate resistance to virus infection

Study of the mechanism of innate resistance to virus infection

The concept of genetically-determined natural resistance was explored in two mouse strains of different genetic origin exposed to West Nile encephalitis virus and yellow fever virus. The inheritance of virus resistance was studied by the cross-breeding of virus-resistant male mice with virus-suscept...

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Veröffentlicht in:Journal of cellular and comparative physiology 1962-06, Vol.59 (3), p.333-373
Hauptverfasser: Goodman, Gail Theis, Koprowski, Hilary
Format: Artikel
Sprache:eng
Schlagworte:
ANIMAL CELLS
BASIC BIOLOGICAL SCIENCES
Biochemical Phenomena
GENETICS
Humans
IMMUNITY
INFECTIONS
LYMPH SYSTEM
MACROPHAGES
MICE
Old Medline
SENSITIVITY
Virus Diseases - immunology
VIRUSES
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Beschreibung
Zusammenfassung:The concept of genetically-determined natural resistance was explored in two mouse strains of different genetic origin exposed to West Nile encephalitis virus and yellow fever virus. The inheritance of virus resistance was studied by the cross-breeding of virus-resistant male mice with virus-susceptible mice of the other strain. Data are tabulated and results are discussed. The mechanism of natural resistance appeared to be expressed at the cellular level in a cell type described as the macrophage.
ISSN:0095-9898
1553-0809
DOI:10.1002/jcp.1030590313