Recovery from Radiation Injury in the Hamster as Evaluated by the Split-Dose Technique
The split-dose technique was used to determine the pattern of recovery from radiation injury in the Syrian hamster. Exposure of the animals to 1-mVp X-rays resulted in a${\rm LD}_{50(30)}$of 941 R. Recovery during the first 20 days was found to be nonexponential; in fact, a marked transient increase...
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| Veröffentlicht in: | Radiation research 1968-01, Vol.33 (1), p.37-49 |
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| container_issue | 1 |
| container_start_page | 37 |
| container_title | Radiation research |
| container_volume | 33 |
| creator | Holloway, R. J. Leong, G. F. Ainsworth, E. J. Albright, M. L. Baum, S. J. |
| description | The split-dose technique was used to determine the pattern of recovery from radiation injury in the Syrian hamster. Exposure of the animals to 1-mVp X-rays resulted in a${\rm LD}_{50(30)}$of 941 R. Recovery during the first 20 days was found to be nonexponential; in fact, a marked transient increase in radiosensitivity was observed during the second week after a conditioning exposure to 2/3${\rm LD}_{50(30)}$. The patterns of changes in erythrocytes, granulocytes, thrombocytes, and mononuclear cells are discussed in light of the change in the time-dependent radiosensitivity. Survival time was found to be inversely related to exposure-the higher the exposure, the shorter the survival time-in all irradiated groups except the group challenged at 3 days. The survival time at the${\rm LD}_{50(30)}$varied with the day of challenge. |
| doi_str_mv | 10.2307/3572240 |
| format | Article |
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J. ; Leong, G. F. ; Ainsworth, E. J. ; Albright, M. L. ; Baum, S. J.</creator><creatorcontrib>Holloway, R. J. ; Leong, G. F. ; Ainsworth, E. J. ; Albright, M. L. ; Baum, S. J. ; Naval Radiological Defense Lab., San Francisco</creatorcontrib><description>The split-dose technique was used to determine the pattern of recovery from radiation injury in the Syrian hamster. Exposure of the animals to 1-mVp X-rays resulted in a${\rm LD}_{50(30)}$of 941 R. Recovery during the first 20 days was found to be nonexponential; in fact, a marked transient increase in radiosensitivity was observed during the second week after a conditioning exposure to 2/3${\rm LD}_{50(30)}$. The patterns of changes in erythrocytes, granulocytes, thrombocytes, and mononuclear cells are discussed in light of the change in the time-dependent radiosensitivity. Survival time was found to be inversely related to exposure-the higher the exposure, the shorter the survival time-in all irradiated groups except the group challenged at 3 days. 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J.</creatorcontrib><creatorcontrib>Leong, G. F.</creatorcontrib><creatorcontrib>Ainsworth, E. J.</creatorcontrib><creatorcontrib>Albright, M. L.</creatorcontrib><creatorcontrib>Baum, S. J.</creatorcontrib><creatorcontrib>Naval Radiological Defense Lab., San Francisco</creatorcontrib><title>Recovery from Radiation Injury in the Hamster as Evaluated by the Split-Dose Technique</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>The split-dose technique was used to determine the pattern of recovery from radiation injury in the Syrian hamster. Exposure of the animals to 1-mVp X-rays resulted in a${\rm LD}_{50(30)}$of 941 R. Recovery during the first 20 days was found to be nonexponential; in fact, a marked transient increase in radiosensitivity was observed during the second week after a conditioning exposure to 2/3${\rm LD}_{50(30)}$. The patterns of changes in erythrocytes, granulocytes, thrombocytes, and mononuclear cells are discussed in light of the change in the time-dependent radiosensitivity. Survival time was found to be inversely related to exposure-the higher the exposure, the shorter the survival time-in all irradiated groups except the group challenged at 3 days. The survival time at the${\rm LD}_{50(30)}$varied with the day of challenge.</description><subject>ABUNDANCE</subject><subject>Animals</subject><subject>Cricetinae</subject><subject>ERYTHROCYTES</subject><subject>Erythrocytes - radiation effects</subject><subject>ERYTHROCYTES/radiation effects on count of, in blood of hamsters, x</subject><subject>Granulocytes</subject><subject>HAMSTERS</subject><subject>HAMSTERS/radiation effects on, use of split-dose technique to determine recovery from injurious</subject><subject>Hematocrit</subject><subject>Irradiation</subject><subject>LEUCOCYTES</subject><subject>Leukocyte Count</subject><subject>Leukocytes</subject><subject>LEUKOCYTES/radiation effects on count of, in blood of hamsters, x</subject><subject>Linear regression</subject><subject>Male</subject><subject>Mortality</subject><subject>N28620 -Life Sciences-Radiation Effects on Animals- Vertebrates</subject><subject>Radiation dosage</subject><subject>RADIATION DOSES</subject><subject>RADIATION INJURIES</subject><subject>Radiation Injuries, Experimental - mortality</subject><subject>Radiation tolerance</subject><subject>Radiometry</subject><subject>RECOVERY</subject><subject>SURVIVAL TIME</subject><subject>TIME</subject><subject>X RADIATION</subject><subject>X RADIATION/effects on hamsters, effects of dose fractionation on recovery from</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kNFKwzAUhoMoc07xCYQgglfVNCdtk0uZ0w0GwpzeljRNWcbWzCQd7O2Ndnjn1eGc7-Pn8CN0nZIHCqR4hKyglJETNEwF8CRjhJ2iISEASZHx4hxdeL8mcU9zMUCDLAcmCjFEnwut7F67A26c3eKFrI0MxrZ41q67eDUtDiuNp3Lrg3ZYejzZy00ng65xdfhl77uNCcmz9RovtVq15qvTl-iskRuvr45zhD5eJsvxNJm_vc7GT_NEAdCQAJU5KahUhBWpqLhQotYVpAXUIqM8p5JkTbwwxTgHTnhKoQKqIqpIrgiM0G2fa30wpVcmxA-UbVutQskyEJznUbrvJeWs90435c6ZrXSHMiXlT3vlsb1o3vTmrqu2uv7zjnVFftfztQ_W_RvzDePlcrI</recordid><startdate>19680101</startdate><enddate>19680101</enddate><creator>Holloway, R. J.</creator><creator>Leong, G. F.</creator><creator>Ainsworth, E. J.</creator><creator>Albright, M. L.</creator><creator>Baum, S. J.</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19680101</creationdate><title>Recovery from Radiation Injury in the Hamster as Evaluated by the Split-Dose Technique</title><author>Holloway, R. J. ; Leong, G. F. ; Ainsworth, E. J. ; Albright, M. L. ; Baum, S. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-32a6072ac04719b89c9deb3173d952862a05fdeb4c4883808123b32c286b06c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>ABUNDANCE</topic><topic>Animals</topic><topic>Cricetinae</topic><topic>ERYTHROCYTES</topic><topic>Erythrocytes - radiation effects</topic><topic>ERYTHROCYTES/radiation effects on count of, in blood of hamsters, x</topic><topic>Granulocytes</topic><topic>HAMSTERS</topic><topic>HAMSTERS/radiation effects on, use of split-dose technique to determine recovery from injurious</topic><topic>Hematocrit</topic><topic>Irradiation</topic><topic>LEUCOCYTES</topic><topic>Leukocyte Count</topic><topic>Leukocytes</topic><topic>LEUKOCYTES/radiation effects on count of, in blood of hamsters, x</topic><topic>Linear regression</topic><topic>Male</topic><topic>Mortality</topic><topic>N28620 -Life Sciences-Radiation Effects on Animals- Vertebrates</topic><topic>Radiation dosage</topic><topic>RADIATION DOSES</topic><topic>RADIATION INJURIES</topic><topic>Radiation Injuries, Experimental - mortality</topic><topic>Radiation tolerance</topic><topic>Radiometry</topic><topic>RECOVERY</topic><topic>SURVIVAL TIME</topic><topic>TIME</topic><topic>X RADIATION</topic><topic>X RADIATION/effects on hamsters, effects of dose fractionation on recovery from</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holloway, R. J.</creatorcontrib><creatorcontrib>Leong, G. F.</creatorcontrib><creatorcontrib>Ainsworth, E. J.</creatorcontrib><creatorcontrib>Albright, M. L.</creatorcontrib><creatorcontrib>Baum, S. J.</creatorcontrib><creatorcontrib>Naval Radiological Defense Lab., San Francisco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holloway, R. J.</au><au>Leong, G. F.</au><au>Ainsworth, E. J.</au><au>Albright, M. L.</au><au>Baum, S. J.</au><aucorp>Naval Radiological Defense Lab., San Francisco</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recovery from Radiation Injury in the Hamster as Evaluated by the Split-Dose Technique</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1968-01-01</date><risdate>1968</risdate><volume>33</volume><issue>1</issue><spage>37</spage><epage>49</epage><pages>37-49</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>The split-dose technique was used to determine the pattern of recovery from radiation injury in the Syrian hamster. Exposure of the animals to 1-mVp X-rays resulted in a${\rm LD}_{50(30)}$of 941 R. Recovery during the first 20 days was found to be nonexponential; in fact, a marked transient increase in radiosensitivity was observed during the second week after a conditioning exposure to 2/3${\rm LD}_{50(30)}$. The patterns of changes in erythrocytes, granulocytes, thrombocytes, and mononuclear cells are discussed in light of the change in the time-dependent radiosensitivity. Survival time was found to be inversely related to exposure-the higher the exposure, the shorter the survival time-in all irradiated groups except the group challenged at 3 days. The survival time at the${\rm LD}_{50(30)}$varied with the day of challenge.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>5634979</pmid><doi>10.2307/3572240</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiation research, 1968-01, Vol.33 (1), p.37-49 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_osti_scitechconnect_4539886 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | ABUNDANCE Animals Cricetinae ERYTHROCYTES Erythrocytes - radiation effects ERYTHROCYTES/radiation effects on count of, in blood of hamsters, x Granulocytes HAMSTERS HAMSTERS/radiation effects on, use of split-dose technique to determine recovery from injurious Hematocrit Irradiation LEUCOCYTES Leukocyte Count Leukocytes LEUKOCYTES/radiation effects on count of, in blood of hamsters, x Linear regression Male Mortality N28620 -Life Sciences-Radiation Effects on Animals- Vertebrates Radiation dosage RADIATION DOSES RADIATION INJURIES Radiation Injuries, Experimental - mortality Radiation tolerance Radiometry RECOVERY SURVIVAL TIME TIME X RADIATION X RADIATION/effects on hamsters, effects of dose fractionation on recovery from |
| title | Recovery from Radiation Injury in the Hamster as Evaluated by the Split-Dose Technique |
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