Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT 1e R and 5-HT 1F R

Serotonin [5-hydroxytryptamine (5-HT)] acts via 13 different receptors in humans. Of these receptor subtypes, all but 5-HT R have confirmed roles in native tissue and are validated drug targets. Despite 5-HT R's therapeutic potential and plausible druggability, the mechanisms of its activation...

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Veröffentlicht in:	Science advances 2024-04, Vol.10 (16), p.eadk4855
Hauptverfasser:	Zilberg, Gregory, Parpounas, Alexandra K, Warren, Audrey L, Fiorillo, Bianca, Provasi, Davide, Filizola, Marta, Wacker, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES Science & Technology - Other Topics
Online-Zugang:	Volltext
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