Mapping structural and dynamic divergence across the MBOAT family

Membrane-bound O-acyltransferases (MBOATs) are membrane-embedded enzymes that catalyze acyl chain transfer to a diverse group of substrates, including lipids, small molecules, and proteins. MBOATs share a conserved structural core, despite wide-ranging functional specificity across both prokaryotes...

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Veröffentlicht in:	Structure (London) 2024-07, Vol.32 (7), p.1011-1022.e3
Hauptverfasser:	Ansell, T. Bertie, Healy, Megan, Coupland, Claire E., Sansom, Mark S.P., Siebold, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - chemistry Acyltransferases - genetics Acyltransferases - metabolism bilayer Binding Sites catalysis Catalytic Domain enzyme Humans Hydrogen Bonding Lipid Bilayers - chemistry Lipid Bilayers - metabolism lipids MBOAT membrane protein molecular dynamics Molecular Dynamics Simulation Protein Binding Protein Multimerization simulation Substrate Specificity
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