Building a Simplistic Automatic Extruder: Instrument Development Opportunities for the Laboratory
This work presents an automatic extruder as a research experience for undergraduate students. The system offers a user-friendly approach to preparing vesicles, such as liposomes or polymersomes, with a defined size and polydispersityproperties crucial for research in biology and macromolecules. It...
Gespeichert in:
| Veröffentlicht in: | Journal of chemical education 2024-08, Vol.101 (8), p.3292-3300 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3300 |
|---|---|
| container_issue | 8 |
| container_start_page | 3292 |
| container_title | Journal of chemical education |
| container_volume | 101 |
| creator | Klisch, Stefanie Gilbert, Dylan Breaux, Emma Dalier, Aliyah Gupta, Sudipta Jakobi, Bruno Schneider, Gerald J. |
| description | This work presents an automatic extruder as a research experience for undergraduate students. The system offers a user-friendly approach to preparing vesicles, such as liposomes or polymersomes, with a defined size and polydispersityproperties crucial for research in biology and macromolecules. It comprises two syringe pumps connected by a membrane filter. The setup is controlled by software. Compared to manual extrusion, this automated system provides advantages, such as precisely controlled variables. The project describes a tool to enhance undergraduate learning in science and engineering laboratories. Building an automatic extruder serves as a simplified model of a complex industrial process. It offers a clear advantage: automating a well-understood manual extrusion process. To make this project accessible, it is broken down into three manageable tasks: software development, hardware assembly, and testing procedures. This breakdown describes the software created, the hardware components used, and the testing procedures conducted for this project. All project data, including software code, testing data, and procedures, are freely available online. This allows undergraduate students to not only begin their own projects but also contribute to this educational instrument’s ongoing development. |
| doi_str_mv | 10.1021/acs.jchemed.4c00287 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_2429679</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3097521516</sourcerecordid><originalsourceid>FETCH-LOGICAL-a325t-b8cbcae11db6230bf6e67f7f75f2be55559fea5dcfa2406c556d1837f7f324b43</originalsourceid><addsrcrecordid>eNp9kUtP3DAUhS1ExUyhvwAJRbDpJoOfebAbprRFGolF6dpynBvGoyQOtoPg39eZx4ZFbcn36uo7x7o6CF0SvCCYklul_WKrN9BBveAaY1rkJ2hOSlakhNHiFM3jjKSlKPgMffV-izGhoizO0IyVROScZXOk7kfT1qZ_SVTyx3RDa3wwOlmOwXZq6h7egxtrcHfJY-9j20Efkh_wBq0ddv3TMFgXxt4EAz5prEvCBpK1qqxTwbqPC_SlUa2Hb4d6jv7-fHhe_U7XT78eV8t1qhgVIa0KXWkFhNRVRhmumgyyvIlXNLQCEU_ZgBK1bhTlONNCZDUp2IQwyivOztH13tfGDaTXJoDeaNv3oIOknJZZXkbo-x4anH0dwQfZGa-hbVUPdvSS4ZLznMc3ojef0K0dXR9XmKhcUCJIFim2p7Sz3jto5OBMp9yHJFhOMckYkzzEJA8xRdXVwXuspvlRc8wlArd7YKc-_vs_y3_rwKHJ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3097521516</pqid></control><display><type>article</type><title>Building a Simplistic Automatic Extruder: Instrument Development Opportunities for the Laboratory</title><source>ACS Publications</source><creator>Klisch, Stefanie ; Gilbert, Dylan ; Breaux, Emma ; Dalier, Aliyah ; Gupta, Sudipta ; Jakobi, Bruno ; Schneider, Gerald J.</creator><creatorcontrib>Klisch, Stefanie ; Gilbert, Dylan ; Breaux, Emma ; Dalier, Aliyah ; Gupta, Sudipta ; Jakobi, Bruno ; Schneider, Gerald J. ; Louisiana State Univ., Baton Rouge, LA (United States)</creatorcontrib><description>This work presents an automatic extruder as a research experience for undergraduate students. The system offers a user-friendly approach to preparing vesicles, such as liposomes or polymersomes, with a defined size and polydispersityproperties crucial for research in biology and macromolecules. It comprises two syringe pumps connected by a membrane filter. The setup is controlled by software. Compared to manual extrusion, this automated system provides advantages, such as precisely controlled variables. The project describes a tool to enhance undergraduate learning in science and engineering laboratories. Building an automatic extruder serves as a simplified model of a complex industrial process. It offers a clear advantage: automating a well-understood manual extrusion process. To make this project accessible, it is broken down into three manageable tasks: software development, hardware assembly, and testing procedures. This breakdown describes the software created, the hardware components used, and the testing procedures conducted for this project. All project data, including software code, testing data, and procedures, are freely available online. This allows undergraduate students to not only begin their own projects but also contribute to this educational instrument’s ongoing development.</description><identifier>ISSN: 0021-9584</identifier><identifier>EISSN: 1938-1328</identifier><identifier>DOI: 10.1021/acs.jchemed.4c00287</identifier><identifier>PMID: 39157436</identifier><language>eng</language><publisher>United States: American Chemical Society and Division of Chemical Education, Inc</publisher><subject>Biology ; College students ; Complex variables ; Computer Software ; Control equipment ; Engineering education ; Extrusion ; Extrusion machines ; Hands-On Learning ; Hardware ; INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY ; Interdisciplinary ; Laboratory Equipment ; Laboratory Instruction ; Lipids ; Membranes ; Polydispersity ; Problem Solving ; Science activities ; Science education ; Software ; Software development ; Students ; Task complexity ; Test procedures ; Testing procedures ; Undergraduate Students ; Undergraduate study ; Upper-Division Undergraduate ; Vesicles</subject><ispartof>Journal of chemical education, 2024-08, Vol.101 (8), p.3292-3300</ispartof><rights>2024 The Authors. Published by American Chemical Society and Division of Chemical Education, Inc.</rights><rights>Copyright American Chemical Society Aug 13, 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a325t-b8cbcae11db6230bf6e67f7f75f2be55559fea5dcfa2406c556d1837f7f324b43</cites><orcidid>0000-0001-6642-3776 ; 0000-0003-1171-9486 ; 0000-0002-5577-9328 ; 0009-0002-1467-9387</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jchemed.4c00287$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jchemed.4c00287$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2764,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39157436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/servlets/purl/2429679$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Klisch, Stefanie</creatorcontrib><creatorcontrib>Gilbert, Dylan</creatorcontrib><creatorcontrib>Breaux, Emma</creatorcontrib><creatorcontrib>Dalier, Aliyah</creatorcontrib><creatorcontrib>Gupta, Sudipta</creatorcontrib><creatorcontrib>Jakobi, Bruno</creatorcontrib><creatorcontrib>Schneider, Gerald J.</creatorcontrib><creatorcontrib>Louisiana State Univ., Baton Rouge, LA (United States)</creatorcontrib><title>Building a Simplistic Automatic Extruder: Instrument Development Opportunities for the Laboratory</title><title>Journal of chemical education</title><addtitle>J. Chem. Educ</addtitle><description>This work presents an automatic extruder as a research experience for undergraduate students. The system offers a user-friendly approach to preparing vesicles, such as liposomes or polymersomes, with a defined size and polydispersityproperties crucial for research in biology and macromolecules. It comprises two syringe pumps connected by a membrane filter. The setup is controlled by software. Compared to manual extrusion, this automated system provides advantages, such as precisely controlled variables. The project describes a tool to enhance undergraduate learning in science and engineering laboratories. Building an automatic extruder serves as a simplified model of a complex industrial process. It offers a clear advantage: automating a well-understood manual extrusion process. To make this project accessible, it is broken down into three manageable tasks: software development, hardware assembly, and testing procedures. This breakdown describes the software created, the hardware components used, and the testing procedures conducted for this project. All project data, including software code, testing data, and procedures, are freely available online. This allows undergraduate students to not only begin their own projects but also contribute to this educational instrument’s ongoing development.</description><subject>Biology</subject><subject>College students</subject><subject>Complex variables</subject><subject>Computer Software</subject><subject>Control equipment</subject><subject>Engineering education</subject><subject>Extrusion</subject><subject>Extrusion machines</subject><subject>Hands-On Learning</subject><subject>Hardware</subject><subject>INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY</subject><subject>Interdisciplinary</subject><subject>Laboratory Equipment</subject><subject>Laboratory Instruction</subject><subject>Lipids</subject><subject>Membranes</subject><subject>Polydispersity</subject><subject>Problem Solving</subject><subject>Science activities</subject><subject>Science education</subject><subject>Software</subject><subject>Software development</subject><subject>Students</subject><subject>Task complexity</subject><subject>Test procedures</subject><subject>Testing procedures</subject><subject>Undergraduate Students</subject><subject>Undergraduate study</subject><subject>Upper-Division Undergraduate</subject><subject>Vesicles</subject><issn>0021-9584</issn><issn>1938-1328</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kUtP3DAUhS1ExUyhvwAJRbDpJoOfebAbprRFGolF6dpynBvGoyQOtoPg39eZx4ZFbcn36uo7x7o6CF0SvCCYklul_WKrN9BBveAaY1rkJ2hOSlakhNHiFM3jjKSlKPgMffV-izGhoizO0IyVROScZXOk7kfT1qZ_SVTyx3RDa3wwOlmOwXZq6h7egxtrcHfJY-9j20Efkh_wBq0ddv3TMFgXxt4EAz5prEvCBpK1qqxTwbqPC_SlUa2Hb4d6jv7-fHhe_U7XT78eV8t1qhgVIa0KXWkFhNRVRhmumgyyvIlXNLQCEU_ZgBK1bhTlONNCZDUp2IQwyivOztH13tfGDaTXJoDeaNv3oIOknJZZXkbo-x4anH0dwQfZGa-hbVUPdvSS4ZLznMc3ojef0K0dXR9XmKhcUCJIFim2p7Sz3jto5OBMp9yHJFhOMckYkzzEJA8xRdXVwXuspvlRc8wlArd7YKc-_vs_y3_rwKHJ</recordid><startdate>20240813</startdate><enddate>20240813</enddate><creator>Klisch, Stefanie</creator><creator>Gilbert, Dylan</creator><creator>Breaux, Emma</creator><creator>Dalier, Aliyah</creator><creator>Gupta, Sudipta</creator><creator>Jakobi, Bruno</creator><creator>Schneider, Gerald J.</creator><general>American Chemical Society and Division of Chemical Education, Inc</general><general>American Chemical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>OIOZB</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0001-6642-3776</orcidid><orcidid>https://orcid.org/0000-0003-1171-9486</orcidid><orcidid>https://orcid.org/0000-0002-5577-9328</orcidid><orcidid>https://orcid.org/0009-0002-1467-9387</orcidid></search><sort><creationdate>20240813</creationdate><title>Building a Simplistic Automatic Extruder: Instrument Development Opportunities for the Laboratory</title><author>Klisch, Stefanie ; Gilbert, Dylan ; Breaux, Emma ; Dalier, Aliyah ; Gupta, Sudipta ; Jakobi, Bruno ; Schneider, Gerald J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a325t-b8cbcae11db6230bf6e67f7f75f2be55559fea5dcfa2406c556d1837f7f324b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biology</topic><topic>College students</topic><topic>Complex variables</topic><topic>Computer Software</topic><topic>Control equipment</topic><topic>Engineering education</topic><topic>Extrusion</topic><topic>Extrusion machines</topic><topic>Hands-On Learning</topic><topic>Hardware</topic><topic>INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY</topic><topic>Interdisciplinary</topic><topic>Laboratory Equipment</topic><topic>Laboratory Instruction</topic><topic>Lipids</topic><topic>Membranes</topic><topic>Polydispersity</topic><topic>Problem Solving</topic><topic>Science activities</topic><topic>Science education</topic><topic>Software</topic><topic>Software development</topic><topic>Students</topic><topic>Task complexity</topic><topic>Test procedures</topic><topic>Testing procedures</topic><topic>Undergraduate Students</topic><topic>Undergraduate study</topic><topic>Upper-Division Undergraduate</topic><topic>Vesicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klisch, Stefanie</creatorcontrib><creatorcontrib>Gilbert, Dylan</creatorcontrib><creatorcontrib>Breaux, Emma</creatorcontrib><creatorcontrib>Dalier, Aliyah</creatorcontrib><creatorcontrib>Gupta, Sudipta</creatorcontrib><creatorcontrib>Jakobi, Bruno</creatorcontrib><creatorcontrib>Schneider, Gerald J.</creatorcontrib><creatorcontrib>Louisiana State Univ., Baton Rouge, LA (United States)</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV - Hybrid</collection><collection>OSTI.GOV</collection><jtitle>Journal of chemical education</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klisch, Stefanie</au><au>Gilbert, Dylan</au><au>Breaux, Emma</au><au>Dalier, Aliyah</au><au>Gupta, Sudipta</au><au>Jakobi, Bruno</au><au>Schneider, Gerald J.</au><aucorp>Louisiana State Univ., Baton Rouge, LA (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Building a Simplistic Automatic Extruder: Instrument Development Opportunities for the Laboratory</atitle><jtitle>Journal of chemical education</jtitle><addtitle>J. Chem. Educ</addtitle><date>2024-08-13</date><risdate>2024</risdate><volume>101</volume><issue>8</issue><spage>3292</spage><epage>3300</epage><pages>3292-3300</pages><issn>0021-9584</issn><eissn>1938-1328</eissn><abstract>This work presents an automatic extruder as a research experience for undergraduate students. The system offers a user-friendly approach to preparing vesicles, such as liposomes or polymersomes, with a defined size and polydispersityproperties crucial for research in biology and macromolecules. It comprises two syringe pumps connected by a membrane filter. The setup is controlled by software. Compared to manual extrusion, this automated system provides advantages, such as precisely controlled variables. The project describes a tool to enhance undergraduate learning in science and engineering laboratories. Building an automatic extruder serves as a simplified model of a complex industrial process. It offers a clear advantage: automating a well-understood manual extrusion process. To make this project accessible, it is broken down into three manageable tasks: software development, hardware assembly, and testing procedures. This breakdown describes the software created, the hardware components used, and the testing procedures conducted for this project. All project data, including software code, testing data, and procedures, are freely available online. This allows undergraduate students to not only begin their own projects but also contribute to this educational instrument’s ongoing development.</abstract><cop>United States</cop><pub>American Chemical Society and Division of Chemical Education, Inc</pub><pmid>39157436</pmid><doi>10.1021/acs.jchemed.4c00287</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6642-3776</orcidid><orcidid>https://orcid.org/0000-0003-1171-9486</orcidid><orcidid>https://orcid.org/0000-0002-5577-9328</orcidid><orcidid>https://orcid.org/0009-0002-1467-9387</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9584 |
| ispartof | Journal of chemical education, 2024-08, Vol.101 (8), p.3292-3300 |
| issn | 0021-9584 1938-1328 |
| language | eng |
| recordid | cdi_osti_scitechconnect_2429679 |
| source | ACS Publications |
| subjects | Biology College students Complex variables Computer Software Control equipment Engineering education Extrusion Extrusion machines Hands-On Learning Hardware INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Interdisciplinary Laboratory Equipment Laboratory Instruction Lipids Membranes Polydispersity Problem Solving Science activities Science education Software Software development Students Task complexity Test procedures Testing procedures Undergraduate Students Undergraduate study Upper-Division Undergraduate Vesicles |
| title | Building a Simplistic Automatic Extruder: Instrument Development Opportunities for the Laboratory |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T22%3A23%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Building%20a%20Simplistic%20Automatic%20Extruder:%20Instrument%20Development%20Opportunities%20for%20the%20Laboratory&rft.jtitle=Journal%20of%20chemical%20education&rft.au=Klisch,%20Stefanie&rft.aucorp=Louisiana%20State%20Univ.,%20Baton%20Rouge,%20LA%20(United%20States)&rft.date=2024-08-13&rft.volume=101&rft.issue=8&rft.spage=3292&rft.epage=3300&rft.pages=3292-3300&rft.issn=0021-9584&rft.eissn=1938-1328&rft_id=info:doi/10.1021/acs.jchemed.4c00287&rft_dat=%3Cproquest_osti_%3E3097521516%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3097521516&rft_id=info:pmid/39157436&rfr_iscdi=true |