Improving Dose-Optimization Processes Used in Oncology Drug Development to Minimize Toxicity and Maximize Benefit to Patients

This review highlights strategies to integrate dose optimization into premarketing drug development and discusses the underlying statistical principles. Poor dose optimization can have negative consequences for patients, most commonly because of toxicity, including poor quality of life, reduced effe...

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Veröffentlicht in:	Journal of clinical oncology 2022-10, Vol.40 (30), p.3489-3500
Hauptverfasser:	Fourie Zirkelbach, Jeanne, Shah, Mirat, Vallejo, Jonathon, Cheng, Joyce, Ayyoub, Amal, Liu, Jiang, Hudson, Rachel, Sridhara, Rajeshwari, Ison, Gwynn, Amiri-Kordestani, Laleh, Tang, Shenghui, Gwise, Thomas, Rahman, Atiqur, Pazdur, Richard, Theoret, Marc R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Oncology
Online-Zugang:	Volltext
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