Design and synthesis of astatinated benzothiazole compounds for their potential use in Targeted Alpha Therapy (TAT) strategies to treat Alzheimer's disease-associated amyloid plaques

Alzheimer's disease (AD) is a terminal neurodegenerative disease characterized by the buildup of amyloid fibrils, amorphous aggregates and tauopathies. Several treatment modalities, which rely on various biological processes to reduce disease burden, have been largely ineffective at treating Al...

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Veröffentlicht in:	Applied radiation and isotopes 2023-01, Vol.191 (C), p.110555-110555, Article 110555
Hauptverfasser:	Kirkeby, Emily K., Chyan, Ming-Kuan, Diehl, George, Wilbur, D. Scott, Li, Yawen, Roberts, Andrew G., Mastren, Tara
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid Astatine-211 Chemistry Copper catalyzed astatination Nuclear Science & Technology Radiochemistry Radiology, Nuclear Medicine & Medical Imaging Targeted alpha therapy
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