The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases

The wide spread of carbapenem-hydrolyzing β-lactamases in Gram-negative bacteria has diminished the utility of the last-resort carbapenem antibiotics, significantly narrowing the available therapeutic options. In the Enterobacteriaceae family, which includes many important clinical pathogens such as...

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Veröffentlicht in:	ACS infectious diseases 2023-05, Vol.9 (5), p.1123-1136
Hauptverfasser:	Smith, Clyde A., Stewart, Nichole K., Toth, Marta, Quan, Pojun, Buynak, John D., Vakulenko, Sergei B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology beta-Lactamases - metabolism Carbapenems - pharmacology Escherichia coli - metabolism Infectious Diseases Kinetics Klebsiella - metabolism Meropenem - pharmacology Pharmacology & Pharmacy
Online-Zugang:	Volltext
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