Plasmid Copy Number Engineering Accelerates Fungal Polyketide Discovery upon Unnatural Polyketide Biosynthesis

Saccharomyces cerevisiae has been extensively used as a convenient synthetic biology chassis to reconstitute fungal polyketide biosynthetic pathways. Despite progress in refactoring these pathways for expression and optimization of the yeast production host by metabolic engineering, product yields o...

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Veröffentlicht in:	ACS synthetic biology 2023-08, Vol.12 (8), p.2226-2235
Hauptverfasser:	Li, Ye, Lin, Pingxin, Lu, Xuan, Yan, Hao, Wei, Huan, Liu, Chunli, Liu, Xiuxia, Yang, Yankun, Molnár, István, Bai, Zhonghu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry & Molecular Biology
Online-Zugang:	Volltext
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