Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily

Radical S -adenosylmethionine (SAM) enzymes use a site-differentiated [4Fe-4S] cluster and SAM to initiate radical reactions through liberation of the 5′-deoxyadenosyl (5′-dAdo*) radical. They form the largest enzyme superfamily, with more than 700,000 unique sequences currently, and their numbers c...

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Veröffentlicht in:	Annual review of biochemistry 2023-06, Vol.92 (1), p.333-349
Hauptverfasser:	Hoffman, Brian M, Broderick, William E, Broderick, Joan B
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-deoxyadenosyl radical Adenosylmethionine BASIC BIOLOGICAL SCIENCES Biochemistry & Molecular Biology Bioinformatics Chemical reactions Enzymes INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Iron-Sulfur Proteins - chemistry Iron-Sulfur Proteins - genetics Jahn-Teller effect organometallic radical SAM Regioselectivity S-Adenosylmethionine S-Adenosylmethionine - chemistry
Online-Zugang:	Volltext
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