Canister valve and actuator deposition in metered dose inhalers formulated with low-GWP propellants

A challenge in pressurised metered-dose inhaler (pMDI) formulation design is management of adhesion of the drug to the canister wall, valve and actuator internal components and surfaces. Wall-material interactions differ between transparent vials used for visual inspection and metal canister pMDI sy...

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Veröffentlicht in:	International journal of pharmaceutics 2023-12, Vol.648, p.123569-123569, Article 123569
Hauptverfasser:	Duke, Daniel J., Rao, Lingzhe, Kastengren, Alan, Myatt, Benjamin, Cocks, Phil, Stein, Stephen, Marasini, Nirmal, Ong, Hui Xin, Young, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES deposition fluorescence green propellants metered dose inhaler sedimentation X-ray
Online-Zugang:	Volltext
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