A Unique Representation of Heat Allodynia in the Human Brain
Skin inflammation causes innocuous heat to become painful. This condition, called heat allodynia, is a common feature of pathological pain states. Here, we show that heat allodynia is functionally and neuroanatomically distinct from normal heat pain. We subtracted positron emission tomography scans...
Gespeichert in:
| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2002-07, Vol.35 (2), p.383-393 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 393 |
|---|---|
| container_issue | 2 |
| container_start_page | 383 |
| container_title | Neuron (Cambridge, Mass.) |
| container_volume | 35 |
| creator | Lorenz, Jürgen Cross, Donna J. Minoshima, Satoshi Morrow, Thomas J. Paulson, Pamela E. Casey, Kenneth L. |
| description | Skin inflammation causes innocuous heat to become painful. This condition, called heat allodynia, is a common feature of pathological pain states. Here, we show that heat allodynia is functionally and neuroanatomically distinct from normal heat pain. We subtracted positron emission tomography scans obtained during painful heating of normal skin from scans during equally intense but normally innocuous heating of capsaicin-treated skin. This comparison reveals the specific activation of a medial thalamic pathway to the frontal lobe during heat allodynia. The results suggest that different central pathways mediate the intensity and certain qualitative aspects of pain. In making this differentiation, the brain recognizes unique physiological features of different painful conditions, thus permitting adaptive responses to different pain states. |
| doi_str_mv | 10.1016/S0896-6273(02)00767-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_2339669</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0896627302007675</els_id><sourcerecordid>18448604</sourcerecordid><originalsourceid>FETCH-LOGICAL-c546t-c645bf7393024088337a072f0b3cf8911da3affc12223171a1307cb5ed9737b53</originalsourceid><addsrcrecordid>eNqFkdFqFDEUQIModlv9BGVQKPowem8ySSYgyFpst1AQ1D6HTCZDU2aTbZIR-vfOdBeFvvQpLyf3cu4h5A3CJwQUn39Bq0QtqGQfgH4EkELW_BlZIShZN6jUc7L6hxyR45xvAbDhCl-SI6QoQHK-Il_W1XXwd5OrfrpdctmFYoqPoYpDtXGmVOtxjP198KbyoSo3rtpMWxOqb8n48Iq8GMyY3evDe0Kuz7__PtvUVz8uLs_WV7XljSi1FQ3vBskUA9pA2zImDUg6QMfs0CrE3jAzDBYppQwlGmQgbcddrySTHWcn5N1-bszF62x9cfbGxhCcLZoypoRQM3S6h3Ypzj656K3P1o2jCS5OWUtUEjjgkyC2TdMKaGbw_SPwNk4pzKYaOTApGuQLxfeUTTHn5Aa9S35r0r1G0Esq_ZBKLx00UP2QSi9Sbw_Tp27r-v-_Dm1m4OsecPNp_3iXFnMXrOt9WsT76J9Y8RfgeJ7v</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503764154</pqid></control><display><type>article</type><title>A Unique Representation of Heat Allodynia in the Human Brain</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Lorenz, Jürgen ; Cross, Donna J. ; Minoshima, Satoshi ; Morrow, Thomas J. ; Paulson, Pamela E. ; Casey, Kenneth L.</creator><creatorcontrib>Lorenz, Jürgen ; Cross, Donna J. ; Minoshima, Satoshi ; Morrow, Thomas J. ; Paulson, Pamela E. ; Casey, Kenneth L.</creatorcontrib><description>Skin inflammation causes innocuous heat to become painful. This condition, called heat allodynia, is a common feature of pathological pain states. Here, we show that heat allodynia is functionally and neuroanatomically distinct from normal heat pain. We subtracted positron emission tomography scans obtained during painful heating of normal skin from scans during equally intense but normally innocuous heating of capsaicin-treated skin. This comparison reveals the specific activation of a medial thalamic pathway to the frontal lobe during heat allodynia. The results suggest that different central pathways mediate the intensity and certain qualitative aspects of pain. In making this differentiation, the brain recognizes unique physiological features of different painful conditions, thus permitting adaptive responses to different pain states.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/S0896-6273(02)00767-5</identifier><identifier>PMID: 12160755</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Afferent Pathways - anatomy & histology ; Afferent Pathways - diagnostic imaging ; Afferent Pathways - physiology ; Brain - anatomy & histology ; Brain - diagnostic imaging ; Brain - physiology ; Brain Mapping ; Capsaicin - pharmacology ; Cerebrovascular Circulation - drug effects ; Cerebrovascular Circulation - physiology ; Functional Laterality - drug effects ; Functional Laterality - physiology ; Heat ; Humans ; Hyperalgesia - etiology ; Hyperalgesia - pathology ; Hyperalgesia - physiopathology ; Inflammation - complications ; Male ; Medical research ; Nerve Fibers - drug effects ; Nerve Fibers - physiology ; Nerve Fibers, Myelinated - drug effects ; Nerve Fibers, Myelinated - physiology ; Nociceptors - physiology ; Pain ; Pain Measurement - drug effects ; Pain Threshold - drug effects ; Pain Threshold - physiology ; Skin - drug effects ; Skin - innervation ; Skin - physiopathology ; Tomography, Emission-Computed ; Wound healing</subject><ispartof>Neuron (Cambridge, Mass.), 2002-07, Vol.35 (2), p.383-393</ispartof><rights>2002 Cell Press</rights><rights>Copyright Elsevier Limited Jul 18, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-c645bf7393024088337a072f0b3cf8911da3affc12223171a1307cb5ed9737b53</citedby><cites>FETCH-LOGICAL-c546t-c645bf7393024088337a072f0b3cf8911da3affc12223171a1307cb5ed9737b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0896-6273(02)00767-5$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12160755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/2339669$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Lorenz, Jürgen</creatorcontrib><creatorcontrib>Cross, Donna J.</creatorcontrib><creatorcontrib>Minoshima, Satoshi</creatorcontrib><creatorcontrib>Morrow, Thomas J.</creatorcontrib><creatorcontrib>Paulson, Pamela E.</creatorcontrib><creatorcontrib>Casey, Kenneth L.</creatorcontrib><title>A Unique Representation of Heat Allodynia in the Human Brain</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>Skin inflammation causes innocuous heat to become painful. This condition, called heat allodynia, is a common feature of pathological pain states. Here, we show that heat allodynia is functionally and neuroanatomically distinct from normal heat pain. We subtracted positron emission tomography scans obtained during painful heating of normal skin from scans during equally intense but normally innocuous heating of capsaicin-treated skin. This comparison reveals the specific activation of a medial thalamic pathway to the frontal lobe during heat allodynia. The results suggest that different central pathways mediate the intensity and certain qualitative aspects of pain. In making this differentiation, the brain recognizes unique physiological features of different painful conditions, thus permitting adaptive responses to different pain states.</description><subject>Adult</subject><subject>Afferent Pathways - anatomy & histology</subject><subject>Afferent Pathways - diagnostic imaging</subject><subject>Afferent Pathways - physiology</subject><subject>Brain - anatomy & histology</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiology</subject><subject>Brain Mapping</subject><subject>Capsaicin - pharmacology</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Functional Laterality - drug effects</subject><subject>Functional Laterality - physiology</subject><subject>Heat</subject><subject>Humans</subject><subject>Hyperalgesia - etiology</subject><subject>Hyperalgesia - pathology</subject><subject>Hyperalgesia - physiopathology</subject><subject>Inflammation - complications</subject><subject>Male</subject><subject>Medical research</subject><subject>Nerve Fibers - drug effects</subject><subject>Nerve Fibers - physiology</subject><subject>Nerve Fibers, Myelinated - drug effects</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>Nociceptors - physiology</subject><subject>Pain</subject><subject>Pain Measurement - drug effects</subject><subject>Pain Threshold - drug effects</subject><subject>Pain Threshold - physiology</subject><subject>Skin - drug effects</subject><subject>Skin - innervation</subject><subject>Skin - physiopathology</subject><subject>Tomography, Emission-Computed</subject><subject>Wound healing</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFqFDEUQIModlv9BGVQKPowem8ySSYgyFpst1AQ1D6HTCZDU2aTbZIR-vfOdBeFvvQpLyf3cu4h5A3CJwQUn39Bq0QtqGQfgH4EkELW_BlZIShZN6jUc7L6hxyR45xvAbDhCl-SI6QoQHK-Il_W1XXwd5OrfrpdctmFYoqPoYpDtXGmVOtxjP198KbyoSo3rtpMWxOqb8n48Iq8GMyY3evDe0Kuz7__PtvUVz8uLs_WV7XljSi1FQ3vBskUA9pA2zImDUg6QMfs0CrE3jAzDBYppQwlGmQgbcddrySTHWcn5N1-bszF62x9cfbGxhCcLZoypoRQM3S6h3Ypzj656K3P1o2jCS5OWUtUEjjgkyC2TdMKaGbw_SPwNk4pzKYaOTApGuQLxfeUTTHn5Aa9S35r0r1G0Esq_ZBKLx00UP2QSi9Sbw_Tp27r-v-_Dm1m4OsecPNp_3iXFnMXrOt9WsT76J9Y8RfgeJ7v</recordid><startdate>20020718</startdate><enddate>20020718</enddate><creator>Lorenz, Jürgen</creator><creator>Cross, Donna J.</creator><creator>Minoshima, Satoshi</creator><creator>Morrow, Thomas J.</creator><creator>Paulson, Pamela E.</creator><creator>Casey, Kenneth L.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20020718</creationdate><title>A Unique Representation of Heat Allodynia in the Human Brain</title><author>Lorenz, Jürgen ; Cross, Donna J. ; Minoshima, Satoshi ; Morrow, Thomas J. ; Paulson, Pamela E. ; Casey, Kenneth L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-c645bf7393024088337a072f0b3cf8911da3affc12223171a1307cb5ed9737b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Afferent Pathways - anatomy & histology</topic><topic>Afferent Pathways - diagnostic imaging</topic><topic>Afferent Pathways - physiology</topic><topic>Brain - anatomy & histology</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - physiology</topic><topic>Brain Mapping</topic><topic>Capsaicin - pharmacology</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Functional Laterality - drug effects</topic><topic>Functional Laterality - physiology</topic><topic>Heat</topic><topic>Humans</topic><topic>Hyperalgesia - etiology</topic><topic>Hyperalgesia - pathology</topic><topic>Hyperalgesia - physiopathology</topic><topic>Inflammation - complications</topic><topic>Male</topic><topic>Medical research</topic><topic>Nerve Fibers - drug effects</topic><topic>Nerve Fibers - physiology</topic><topic>Nerve Fibers, Myelinated - drug effects</topic><topic>Nerve Fibers, Myelinated - physiology</topic><topic>Nociceptors - physiology</topic><topic>Pain</topic><topic>Pain Measurement - drug effects</topic><topic>Pain Threshold - drug effects</topic><topic>Pain Threshold - physiology</topic><topic>Skin - drug effects</topic><topic>Skin - innervation</topic><topic>Skin - physiopathology</topic><topic>Tomography, Emission-Computed</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lorenz, Jürgen</creatorcontrib><creatorcontrib>Cross, Donna J.</creatorcontrib><creatorcontrib>Minoshima, Satoshi</creatorcontrib><creatorcontrib>Morrow, Thomas J.</creatorcontrib><creatorcontrib>Paulson, Pamela E.</creatorcontrib><creatorcontrib>Casey, Kenneth L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorenz, Jürgen</au><au>Cross, Donna J.</au><au>Minoshima, Satoshi</au><au>Morrow, Thomas J.</au><au>Paulson, Pamela E.</au><au>Casey, Kenneth L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Unique Representation of Heat Allodynia in the Human Brain</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2002-07-18</date><risdate>2002</risdate><volume>35</volume><issue>2</issue><spage>383</spage><epage>393</epage><pages>383-393</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>Skin inflammation causes innocuous heat to become painful. This condition, called heat allodynia, is a common feature of pathological pain states. Here, we show that heat allodynia is functionally and neuroanatomically distinct from normal heat pain. We subtracted positron emission tomography scans obtained during painful heating of normal skin from scans during equally intense but normally innocuous heating of capsaicin-treated skin. This comparison reveals the specific activation of a medial thalamic pathway to the frontal lobe during heat allodynia. The results suggest that different central pathways mediate the intensity and certain qualitative aspects of pain. In making this differentiation, the brain recognizes unique physiological features of different painful conditions, thus permitting adaptive responses to different pain states.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12160755</pmid><doi>10.1016/S0896-6273(02)00767-5</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0896-6273 |
| ispartof | Neuron (Cambridge, Mass.), 2002-07, Vol.35 (2), p.383-393 |
| issn | 0896-6273 1097-4199 |
| language | eng |
| recordid | cdi_osti_scitechconnect_2339669 |
| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Afferent Pathways - anatomy & histology Afferent Pathways - diagnostic imaging Afferent Pathways - physiology Brain - anatomy & histology Brain - diagnostic imaging Brain - physiology Brain Mapping Capsaicin - pharmacology Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Functional Laterality - drug effects Functional Laterality - physiology Heat Humans Hyperalgesia - etiology Hyperalgesia - pathology Hyperalgesia - physiopathology Inflammation - complications Male Medical research Nerve Fibers - drug effects Nerve Fibers - physiology Nerve Fibers, Myelinated - drug effects Nerve Fibers, Myelinated - physiology Nociceptors - physiology Pain Pain Measurement - drug effects Pain Threshold - drug effects Pain Threshold - physiology Skin - drug effects Skin - innervation Skin - physiopathology Tomography, Emission-Computed Wound healing |
| title | A Unique Representation of Heat Allodynia in the Human Brain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T22%3A14%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Unique%20Representation%20of%20Heat%20Allodynia%20in%20the%20Human%20Brain&rft.jtitle=Neuron%20(Cambridge,%20Mass.)&rft.au=Lorenz,%20J%C3%BCrgen&rft.date=2002-07-18&rft.volume=35&rft.issue=2&rft.spage=383&rft.epage=393&rft.pages=383-393&rft.issn=0896-6273&rft.eissn=1097-4199&rft_id=info:doi/10.1016/S0896-6273(02)00767-5&rft_dat=%3Cproquest_osti_%3E18448604%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1503764154&rft_id=info:pmid/12160755&rft_els_id=S0896627302007675&rfr_iscdi=true |