CD47 blockade enhances therapeutic efficacy of cisplatin against lung carcinoma in a murine model

Cisplatin (CDDP) is the first generation of platinum-based drug and is widely used to treat many cancers due to its potency. The present study aims to explore the effects of CDDP on lung carcinoma and its relationship with macrophage phagocytosis. In in vitro study, murine and human lung cancer cell...

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Veröffentlicht in:	Experimental cell research 2021-08, Vol.405 (2), p.112677-112677, Article 112677
Hauptverfasser:	Cui, Zhilei, Xu, Dengfei, Zhang, Fafu, Sun, Jinyuan, Song, Lin, Ye, Wenjing, Zeng, Junxiang, Zhou, Min, Ruan, Zhengshang, Zhang, Linlin, Ren, Rongrong
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals ANTIBODIES Antineoplastic Agents - pharmacology APOPTOSIS CARCINOMAS CD47 CD47 Antigen - antagonists & inhibitors Cell Line, Tumor Cell Proliferation - drug effects Cisplatin Cisplatin - pharmacology Disease Models, Animal DRUGS ENZYME IMMUNOASSAY ENZYMES Humans IN VITRO IN VIVO INTERFERON Lung carcinoma Lung Neoplasms - drug therapy Lung Neoplasms - pathology LUNGS Macrophage MACROPHAGES MESSENGER-RNA MICE Mice, Inbred C57BL PHAGOCYTOSIS Phagocytosis - drug effects PLATINUM POLYMERASE CHAIN REACTION SURVIVAL TIME TUMOR CELLS
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