Dexmedetomidine preconditioning ameliorates lung injury induced by pulmonary ischemia/reperfusion by upregulating promoter histone H3K4me3 modification of KGF-2

Keratinocyte growth factor (KGF)-2 has been highlighted to play a significant role in maintaining the endothelial barrier integrity in lung injury induced by ischemia-reperfusion (I/R). However, the underlying mechanism remains largely unknown. The aims of this study were to determine whether dexmed...

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Veröffentlicht in:	Experimental cell research 2021-09, Vol.406 (2), p.112762-112762, Article 112762
Hauptverfasser:	Hong, Huisuo, Huang, Qingqing, Cai, Yaoyao, Lin, Tingting, Xia, Fangfang, Jin, Zhousheng
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANIMAL TISSUES Dexmedetomidine Endothelial barrier dysfunction GROWTH FACTORS HISTONES INFLAMMATION INJURIES ISCHEMIA Ischemia/reperfusion JMJD3 KGF-2 Lung injury LUNGS MICE PROMOTERS
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