TRPV4 promotes the migration and invasion of glioma cells via AKT/Rac1 signaling

Experimental evidence indicates a critical role of TRPV4 (Transient Receptor Potential Vanilloid 4) in controlling the cell migratory activity of multiple tumors. However, the oncogenic role of TRPV4 in glioma still remains elusive. In this study, we tried to investigate the oncogenic role of TRPV4...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-09, Vol.503 (2), p.876-881
Hauptverfasser:	Ou-yang, Qing, Li, Bing, Xu, Minhui, Liang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES agonists AKT antagonists Blotting, Western botulinum toxin Cell Line, Tumor Cell Movement Glioma Glioma - metabolism Glioma - pathology GLIOMAS Humans Invasion Leucine - analogs & derivatives Leucine - pharmacology migratory behavior Morpholines - pharmacology Neoplasm Invasiveness PHOSPHORYLATION prognosis Proto-Oncogene Proteins c-akt - metabolism Pyrroles - pharmacology Rac1 rac1 GTP-Binding Protein - metabolism RECEPTORS Signal Transduction Sulfonamides - pharmacology therapeutics THERAPY TOXINS transient receptor potential vanilloid channels TRPV Cation Channels - agonists TRPV Cation Channels - antagonists & inhibitors TRPV Cation Channels - metabolism TRPV4
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