Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice

It is well known that immune-mediated virus elimination is necessary for the treatment of HBV infection. Reconstitution of human immune cells in liver chimeric mice is warranted to understand the immunopathogenesis of HBV infection. Here, we report a new immunologically humanized mouse model with a...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-09, Vol.503 (3), p.1457-1464
Hauptverfasser:	Aono, Satoshi, Tatsumi, Tomohide, Yoshioka, Teppei, Tawara, Seiichi, Nishio, Akira, Onishi, Yoshiki, Fukutomi, Keisuke, Nakabori, Tasuku, Kodama, Takahiro, Shigekawa, Minoru, Hikita, Hayato, Sakamori, Ryotaro, Takahashi, Takeshi, Suemizu, Hiroshi, Takehara, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals ANTIBODIES BLOOD Disease Models, Animal Hep G2 Cells HEPATITIS Hepatitis B virus Hepatitis B virus - immunology Humans HYDRODYNAMICS Immunohumanized mouse INJECTION Leukocytes, Mononuclear - immunology LIVER MICE Mice, Knockout Mice, SCID PEPTIDES T-Lymphocytes - immunology
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