Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells

Near-haploidy is observed in certain cancer types, but ploidy-dependent alterations in gene regulation in the haploid state remain elusive. Here, by comparative transcriptome analysis between human isogenic haploid and diploid cell lines, we found lowering of cyclin D2 level in haploids. Acute genom...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-09, Vol.504 (1), p.231-237
Hauptverfasser:	Yaguchi, Kan, Yamamoto, Takahiro, Shimada, Masaya, Sugimoto, Rina, Nakamura, Kiminori, Ayabe, Tokiyoshi, Uehara, Ryota
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Cyclin D GENE REGULATION HAPLOIDY NEOPLASMS PHOSPHORYLATION Ploidy
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