Targeting CD26 suppresses proliferation of malignant mesothelioma cell via downmodulation of ubiquitin-specific protease 22

Malignant pleural mesothelioma (MPM) is an aggressive malignancy arising from mesothelial lining of pleura. It is associated with a poor prognosis, partly due to the lack of a precise understanding of the molecular mechanisms associated with its malignant behavior. In the present study, we expanded...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-10, Vol.504 (2), p.491-498
Hauptverfasser:	Okamoto, Toshihiro, Yamazaki, Hiroto, Hatano, Ryo, Yamada, Taketo, Kaneko, Yutaro, Xu, C. Wilson, Dang, Nam H., Ohnuma, Kei, Morimoto, Chikao
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Antibodies, Monoclonal, Humanized - pharmacology CD26 CELL CYCLE Cell Line, Tumor CELL PROLIFERATION Dipeptidyl Peptidase 4 - metabolism Dipeptidyl-Peptidase IV Inhibitors - pharmacology Female Gene Expression Profiling HISTONES Humanized anti-CD26 monoclonal antibody Humans Lung Neoplasms - metabolism Malignant pleural mesothelioma Mesothelioma - metabolism Mesothelioma, Malignant Mice Mice, SCID MONOCLONAL ANTIBODIES Neoplasm Transplantation NEOPLASMS PLEURA Pleural Neoplasms - metabolism RNA, Small Interfering - metabolism Thiolester Hydrolases - metabolism Ubiquitin Thiolesterase Ubiquitin-specific protease 22
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