Hypoxia-induced activation of Twist/miR-214/E-cadherin axis promotes renal tubular epithelial cell mesenchymal transition and renal fibrosis

The epithelial-to-mesenchymal transition (EMT) induced by chronic hypoxia is one of the critical causes of renal fibrosis. Previous work reported that the transcription factors Twist plays an important role in hypoxia-induced EMT and renal fibrosis. Recent evidence indicates that miR-214 was regulat...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-01, Vol.495 (3), p.2324-2330
Hauptverfasser:	Liu, Minna, Liu, Limin, Bai, Ming, Zhang, Lei, Ma, Feng, Yang, Xiaoxia, Sun, Shiren
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANOXIA Epithelial mesenchymal transition FIBROSIS Hypoxia KIDNEYS MICE microRNA-214-3p PHENOTYPE PORIFERA Renal fibrosis TRANSCRIPTION FACTORS Twist
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