AZD5153, a novel BRD4 inhibitor, suppresses human thyroid carcinoma cell growth in vitro and in vivo

The development of novel anti-papillary thyroid carcinoma agents is urgent. AZD5153 is a novel and specific Bromodomain-containing protein 4 (BRD4) inhibitor. Here, we show that AZD5153 dose-dependently inhibited survival, proliferation and cell cycle progression in TPC-1 cells and primary human thy...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-05, Vol.499 (3), p.531-537
Hauptverfasser:	Xu, Kun, Chen, Dexuan, Qian, Dong, Zhang, Shihu, Zhang, Yi, Guo, Song, Ma, Zhaoqun, Wang, Shui
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AZD5153 BRD4 CARCINOMAS CELL CYCLE Cell proliferation MICE Molecularly-targeted therapy ORAL ADMINISTRATION Papillary thyroid carcinoma PROTEINS THYROID
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