Investigation of TRPV1 loss-of-function phenotypes in TRPV1 Leu206Stop mice generated by N-ethyl-N-nitrosourea mutagenesis

N-ethyl-N-nitrosourea (ENU) random mutagenesis was used to generate a mouse model for the analysis of the transient receptor potential vanilloid 1 (TRPV1) cation channel. A transversion from T→A in exon 4 led to a Leu206Stop mutation generating a loss-of-function mutant. The TRPV1 agonist capsaicin...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-06, Vol.500 (2), p.456-461
Hauptverfasser:	Christoph, Thomas, Kögel, Babette, Schiene, Klaus, Peters, Thomas, Schröder, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Calcium - metabolism CALCIUM IONS Capsaicin - pharmacology Cells, Cultured Ethylnitrosourea Ganglia, Spinal - metabolism Gene disruption in mice Hyperalgesia - metabolism Hyperalgesia - pathology Ligation Loss of Function Mutation - genetics MICE Mice, Inbred C57BL Mice, Knockout Mutagenesis - genetics NERVE CELLS Neurons - drug effects Neurons - metabolism NITROSOUREAS PAIN Phenotype Potassium - pharmacology RECEPTORS Spinal Nerves - metabolism TRPV Cation Channels - genetics TRPV1
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