Alteration of global protein SUMOylation in neurons and astrocytes in response to Alzheimer's disease-associated insults

SUMOylation, a post-translational modification of lysine residues by small ubiquitin-like modifier (SUMO) proteins, has been implicated in the pathogenesis of neurodegenerative disorders including Alzheimer's disease (AD), and in neuron- and astrocyte-specific physiological functions. Global SU...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-06, Vol.500 (2), p.470-475
Hauptverfasser:	Maruyama, Takuma, Wada, Harmony, Abe, Yoichiro, Niikura, Takako
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - toxicity Amyloid β Animals Astrocytes - drug effects Astrocytes - metabolism BRAIN Cells, Cultured DISEASES Glutamate Glutamic Acid - toxicity Hydrogen peroxide Hydrogen Peroxide - toxicity LYSINE MICE Mice, Inbred C57BL Mice, Inbred ICR Mice, Transgenic NERVE CELLS Neurons - drug effects Neurons - metabolism PATHOGENESIS SUMO Sumoylation
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