Kruppel-like factor 4 (KLF-4) plays a crucial role in simvastatin (SVT)-induced differentiation of rabbit articular chondrocytes

Simvastatin is a cholesterol-lowing reagent that is derived synthetically from the fermentation of Aspergillus terreus. Recently, SVT has been shown to possess a protective effect of chondrocytes. Kruppel-like factor 4 (KLF-4) is a zinc finger transcription factor that plays crucial roles during the...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-06, Vol.501 (3), p.814-819
Hauptverfasser:	Yu, Seon-Mi, Kim, Song Ja
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Anticholesteremic Agents - pharmacology ASPERGILLUS Cartilage, Articular - cytology Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cell Differentiation - drug effects Cells, Cultured CHOLESTEROL Chondrocytes Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism COLLAGEN Differentiation Kruppel-like factor 4 Kruppel-Like Transcription Factors - analysis Kruppel-Like Transcription Factors - metabolism Rabbits Simvastatin Simvastatin - pharmacology SOX9 Transcription Factor - analysis SOX9 Transcription Factor - metabolism TRANSCRIPTION FACTORS
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