Up regulated Tmbim1 activation promotes high fat diet (HFD)-induced cardiomyopathy by enhancement of inflammation and oxidative stress

The prevalence of cardiomyopathy due to metabolic stress has up-regulated dramatically; nevertheless, its molecular mechanisms remain unclear. Here we suggested that transmembrane BAX inhibitor motif-containing 1 (Tmbim1) is down-regulated in the hearts of mice fed with high fat diet (HFD). We provi...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-10, Vol.504 (4), p.797-804
Hauptverfasser:	Gong, Fen, Gu, Junfei, Wang, Haijun
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Cardiomyopathy CREATINE GLUCOSE HEART FAILURE INFLAMMATION LACTATE DEHYDROGENASE LYMPHOKINES Metabolic stress MICE Oxidative stress Tmbim1
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