Elucidation of the crystal structure of FabD from the multidrug-resistant bacterium Acinetobacter baumannii

Bacterial fatty acid synthesis (FAS) has been extensively studied as a potential target of antimicrobials. In FAS, FabD mediates transacylation of the malonyl group from malonyl-CoA to acyl-carrier protein (ACP). The mounting threat of nosocomial infection by multidrug-resistant Acinetobacter bauman...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-10, Vol.505 (1), p.208-214
Hauptverfasser:	Lee, Woo Cheol, Park, Jungwoo, Balasubramanian, Pavithra K., Kim, Yangmee
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acinetobacter baumannii CARBOXYLIC ACIDS CRYSTAL STRUCTURE Fatty acid synthesis Malonyl-CoA acyl-carrier protein transacylase PROTEINS PSEUDOMONAS Trifluoperazine VIRULENCE
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