17β-estradiol protects nucleus pulposus cells from serum deprivation-induced apoptosis and regulates expression of MMP-3 and MMP-13 through promotion of autophagy

Serum deprivation is a likely contributor to intervertebral disc (IVD) degeneration (IVDD).17β-estradiol (E2) have been noted to protect nucleus pulposus cells (NPCs) against apoptosis. Autophagy and apoptosis play a paramount role in maintaining the homeostasis of IVD. So far, little research has b...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-09, Vol.503 (2), p.791-797
Hauptverfasser:	Ao, Peng, Huang, Wenzhou, Li, Jian, Wu, Tianlong, Xu, Libiao, Deng, Zhongbo, Chen, Wenjie, Yin, Changchang, Cheng, Xigao
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-estradiol 60 APPLIED LIFE SCIENCES ADENOVIRUS Animals Apoptosis Autophagy blood serum Cells, Cultured Cytoprotection ESTRADIOL Estradiol - metabolism flow cytometry HOMEOSTASIS Intervertebral disc degeneration intervertebral disks Matrix metalloproteinase Matrix Metalloproteinase 13 - metabolism Matrix Metalloproteinase 3 - metabolism metalloproteinases Nucleus Pulposus - cytology Nucleus Pulposus - metabolism Nucleus pulposus cells protective effect PROTEINS RATS Rats, Sprague-Dawley Serum - metabolism transfection
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