Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells
Resveratrol is a natural polyphenol with several therapeutic effects, in particular, inducing p53-dependent cell cycle arrest and/or apoptosis in tumor cells. Resveratrol-induced p53 activation may trigger differentiation and apoptosis in embryonic stem cells (ESCs). We show that resveratrol activat...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2018-09, Vol.503 (3), p.2180-2185 |
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| creator | Suvorova, Irina I. Knyazeva, Aleksandra R. Pospelov, Valery A. |
| description | Resveratrol is a natural polyphenol with several therapeutic effects, in particular, inducing p53-dependent cell cycle arrest and/or apoptosis in tumor cells. Resveratrol-induced p53 activation may trigger differentiation and apoptosis in embryonic stem cells (ESCs). We show that resveratrol activates p53 that is negatively regulated by SIRT1 deacetylation on Lys379 and positively by AMPK phosphorylation on Ser15 in mouse ESCs (mESCs). Surprisingly, the resveratrol-activated p53 is not associated with either G1/S cell cycle checkpoint or apoptosis in mESCs. Instead, it stimulates autophagy in a transcriptional-dependent manner involving up-regulation of dram1 gene expression. This study demonstrates a novel mechanism of resveratrol-dependent p53 activation in mESCs.
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•Resveratrol-induced p53 activation does not cause G1/S cell cycle checkpoint and differentiation in mESCs.•The level of resveratrol-induced p53 activity is regulated by SIRT1 deacetylation in mESCs.•Resveratrol-activated p53 stimulates autophagy in a transcription-dependent manner in mESCs. |
| doi_str_mv | 10.1016/j.bbrc.2018.08.010 |
| format | Article |
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[Display omitted]
•Resveratrol-induced p53 activation does not cause G1/S cell cycle checkpoint and differentiation in mESCs.•The level of resveratrol-induced p53 activity is regulated by SIRT1 deacetylation in mESCs.•Resveratrol-activated p53 stimulates autophagy in a transcription-dependent manner in mESCs.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2018.08.010</identifier><identifier>PMID: 30098786</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; APOPTOSIS ; Autophagy ; CELL CYCLE ; Embryonic stem cells ; MICE ; p53 ; PHOSPHORYLATION ; Pluripotency ; POLYPHENOLS ; Resveratrol ; SIRT1 ; STEM CELLS ; TUMOR CELLS</subject><ispartof>Biochemical and biophysical research communications, 2018-09, Vol.503 (3), p.2180-2185</ispartof><rights>2018</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-6d9f09eed648d378e6e831800b090052daf1754341cf44513f70ca70d03a155b3</citedby><cites>FETCH-LOGICAL-c384t-6d9f09eed648d378e6e831800b090052daf1754341cf44513f70ca70d03a155b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2018.08.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30098786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/23105560$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Suvorova, Irina I.</creatorcontrib><creatorcontrib>Knyazeva, Aleksandra R.</creatorcontrib><creatorcontrib>Pospelov, Valery A.</creatorcontrib><title>Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Resveratrol is a natural polyphenol with several therapeutic effects, in particular, inducing p53-dependent cell cycle arrest and/or apoptosis in tumor cells. Resveratrol-induced p53 activation may trigger differentiation and apoptosis in embryonic stem cells (ESCs). We show that resveratrol activates p53 that is negatively regulated by SIRT1 deacetylation on Lys379 and positively by AMPK phosphorylation on Ser15 in mouse ESCs (mESCs). Surprisingly, the resveratrol-activated p53 is not associated with either G1/S cell cycle checkpoint or apoptosis in mESCs. Instead, it stimulates autophagy in a transcriptional-dependent manner involving up-regulation of dram1 gene expression. This study demonstrates a novel mechanism of resveratrol-dependent p53 activation in mESCs.
[Display omitted]
•Resveratrol-induced p53 activation does not cause G1/S cell cycle checkpoint and differentiation in mESCs.•The level of resveratrol-induced p53 activity is regulated by SIRT1 deacetylation in mESCs.•Resveratrol-activated p53 stimulates autophagy in a transcription-dependent manner in mESCs.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>APOPTOSIS</subject><subject>Autophagy</subject><subject>CELL CYCLE</subject><subject>Embryonic stem cells</subject><subject>MICE</subject><subject>p53</subject><subject>PHOSPHORYLATION</subject><subject>Pluripotency</subject><subject>POLYPHENOLS</subject><subject>Resveratrol</subject><subject>SIRT1</subject><subject>STEM CELLS</subject><subject>TUMOR CELLS</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMGKFDEQhoMo7uzqC3iQgBcvPVZ1Ot1p8CKLusKCIApeJKSTaifDdGdM0iPz9qaZ1aNQkEO--vnrY-wFwhYB2zf77TBEu60B1RbKIDxiG4Qeqhqhecw2ANBWdY_fr9h1SnsAxKbtn7IrAdCrTrUb9uMLpRNFk2M4VH52iyXHj1JwY7M_mezDzH3iJqVgvcnl87fPO26WHI478_PM_cynsCTiNA3xHGZveco0cUuHQ3rGnozmkOj5w3vDvn14__X2rrr__PHT7bv7ygrV5Kp1_Qg9kWsb5USnqCUlUAEM5RiQtTMjdrIRDdqxaSSKsQNrOnAgDEo5iBv26pIbUvY6WZ_J7myYZ7JZ1wJByhYK9fpCHWP4tVDKevJp7WlmKifoGlTX97KwBa0vqI0hpUijPkY_mXjWCHqVr_d6la9X-RrK4Jr_8iF_GSZy_1b-2i7A2wtAxcXJU1yr0lyU-7g2dcH_L_8Pm4iU8g</recordid><startdate>20180910</startdate><enddate>20180910</enddate><creator>Suvorova, Irina I.</creator><creator>Knyazeva, Aleksandra R.</creator><creator>Pospelov, Valery A.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20180910</creationdate><title>Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells</title><author>Suvorova, Irina I. ; Knyazeva, Aleksandra R. ; Pospelov, Valery A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-6d9f09eed648d378e6e831800b090052daf1754341cf44513f70ca70d03a155b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>APOPTOSIS</topic><topic>Autophagy</topic><topic>CELL CYCLE</topic><topic>Embryonic stem cells</topic><topic>MICE</topic><topic>p53</topic><topic>PHOSPHORYLATION</topic><topic>Pluripotency</topic><topic>POLYPHENOLS</topic><topic>Resveratrol</topic><topic>SIRT1</topic><topic>STEM CELLS</topic><topic>TUMOR CELLS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suvorova, Irina I.</creatorcontrib><creatorcontrib>Knyazeva, Aleksandra R.</creatorcontrib><creatorcontrib>Pospelov, Valery A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suvorova, Irina I.</au><au>Knyazeva, Aleksandra R.</au><au>Pospelov, Valery A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2018-09-10</date><risdate>2018</risdate><volume>503</volume><issue>3</issue><spage>2180</spage><epage>2185</epage><pages>2180-2185</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Resveratrol is a natural polyphenol with several therapeutic effects, in particular, inducing p53-dependent cell cycle arrest and/or apoptosis in tumor cells. Resveratrol-induced p53 activation may trigger differentiation and apoptosis in embryonic stem cells (ESCs). We show that resveratrol activates p53 that is negatively regulated by SIRT1 deacetylation on Lys379 and positively by AMPK phosphorylation on Ser15 in mouse ESCs (mESCs). Surprisingly, the resveratrol-activated p53 is not associated with either G1/S cell cycle checkpoint or apoptosis in mESCs. Instead, it stimulates autophagy in a transcriptional-dependent manner involving up-regulation of dram1 gene expression. This study demonstrates a novel mechanism of resveratrol-dependent p53 activation in mESCs.
[Display omitted]
•Resveratrol-induced p53 activation does not cause G1/S cell cycle checkpoint and differentiation in mESCs.•The level of resveratrol-induced p53 activity is regulated by SIRT1 deacetylation in mESCs.•Resveratrol-activated p53 stimulates autophagy in a transcription-dependent manner in mESCs.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30098786</pmid><doi>10.1016/j.bbrc.2018.08.010</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2018-09, Vol.503 (3), p.2180-2185 |
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| source | Elsevier ScienceDirect Journals |
| subjects | 60 APPLIED LIFE SCIENCES APOPTOSIS Autophagy CELL CYCLE Embryonic stem cells MICE p53 PHOSPHORYLATION Pluripotency POLYPHENOLS Resveratrol SIRT1 STEM CELLS TUMOR CELLS |
| title | Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells |
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