Autophagy impairment in pancreatic acinar cells causes zymogen granule accumulation and pancreatitis

Basal autophagy degrades many kinds of proteins and organelles to maintain quality and plays important roles in cellular homeostasis. However, the impact of basal autophagy on zymogen granules in pancreatic acinar cells is unknown. In the present study, we examined the influence of autophagy impairm...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-09, Vol.503 (4), p.2576-2582
Hauptverfasser:	Iwahashi, Kiyoshi, Hikita, Hayato, Makino, Yuki, Shigekawa, Minoru, Ikezawa, Kenji, Yoshioka, Teppei, Kodama, Takahiro, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acinar Cells - pathology Age Factors Animals Animals, Genetically Modified APOPTOSIS Atg7 ATROPHY Autophagy Autophagy-Related Protein 7 - genetics CELL CONSTITUENTS Chronic Disease Chronic pancreatitis DIGESTIVE SYSTEM DISEASES HOMEOSTASIS LIPASES MICE PANCREAS Pancreas - pathology Pancreatitis Pancreatitis - etiology Secretory Vesicles - metabolism Zymogen granule
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