Resistin destroys mitochondrial biogenesis by inhibiting the PGC-1α/ NRF1/TFAM signaling pathway

Mitochondrial biogenesis deficits in neuronal cells are associated with the pathological progression of neurodegenerative diseases. Resistin, a secretory adipocytokine, possesses multiple physiological functions in diverse cells and tissues. However, the effects of resistin on mitochondrial biogenes...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-09, Vol.504 (1), p.13-18
Hauptverfasser:	Chen, Zhenbo, Tao, Shanwei, Li, Xiaohui, Yao, Qinghe
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ADENOSINE CYTOCHROMES MITOCHONDRIA Mitochondrial biogenesis mtDNA NERVOUS SYSTEM DISEASES Neurodegenerative diseases OXIDASES Peroxisome proliferator activator receptor gamma-coactivator 1α (PGC-1α) RECEPTORS Resistin TRANSCRIPTION FACTORS
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