Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice

Sialadenitis is an inflammatory condition affecting the salivary glands including the parotid, submandibular, and sublingual glands. There are several different types of sialadenitis, each with different sites of predilection. However, the pathogenic mechanism underlying the tissue specificity of si...

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Veröffentlicht in:Biochemical and biophysical research communications 2018-09, Vol.504 (1), p.245-250
Hauptverfasser: Noguchi, Kaori, Kamiyama, Naganori, Hidano, Shinya, Gendo, Yoshiko, Sonoda, Akira, Ozaki, Takashi, Hirose, Haruna, Sachi, Nozomi, Saechue, Benjawan, Ozaka, Sotaro, Eshita, Yuki, Mizukami, Kazuhiro, Kawano, Kenji, Kobayashi, Takashi
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container_title Biochemical and biophysical research communications
container_volume 504
creator Noguchi, Kaori
Kamiyama, Naganori
Hidano, Shinya
Gendo, Yoshiko
Sonoda, Akira
Ozaki, Takashi
Hirose, Haruna
Sachi, Nozomi
Saechue, Benjawan
Ozaka, Sotaro
Eshita, Yuki
Mizukami, Kazuhiro
Kawano, Kenji
Kobayashi, Takashi
description Sialadenitis is an inflammatory condition affecting the salivary glands including the parotid, submandibular, and sublingual glands. There are several different types of sialadenitis, each with different sites of predilection. However, the pathogenic mechanism underlying the tissue specificity of sialadenitis is largely unknown. TRAF6 is a cytoplasmic adaptor protein that is necessary for the activation of dendritic cells in response to Toll-like receptor ligands, thereby regulating innate immune responses. We previously demonstrated that T cell-specific TRAF6-deficient mice (TRAF6ΔT mice) spontaneously develop systemic inflammatory disease. Here, we show that salivary secretion is reduced in TRAF6ΔT mice due to sialadenitis that occurs in the parotid and submandibular glands, but not the sublingual glands. Consistent with pathological findings, both CD4+ and CD8+ T cells predominantly infiltrated the submandibular glands; however, sublingual infiltration was rare in TRAF6ΔT mice. The TH1 cytokine IFN-γ, the TH1 cell attractant chemokine CCL2, and its cognate receptor CCR2 were upregulated concomitantly in both the submandibular and sublingual glands. Interestingly, the TH17 cell attractant chemokine CCL20 and its cognate receptor CCR6 were selectively increased in the submandibular glands, but not in the sublingual glands of TRAF6ΔT mice. Thus, the expression of TRAF6 in T cells might be implicated in tissue-specific sialadenitis by regulating the chemokine-chemokine receptor system.
doi_str_mv 10.1016/j.bbrc.2018.08.162
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The TH1 cytokine IFN-γ, the TH1 cell attractant chemokine CCL2, and its cognate receptor CCR2 were upregulated concomitantly in both the submandibular and sublingual glands. Interestingly, the TH17 cell attractant chemokine CCL20 and its cognate receptor CCR6 were selectively increased in the submandibular glands, but not in the sublingual glands of TRAF6ΔT mice. 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ispartof Biochemical and biophysical research communications, 2018-09, Vol.504 (1), p.245-250
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source ScienceDirect Journals (5 years ago - present)
subjects 60 APPLIED LIFE SCIENCES
Chemokine/chemokine receptor pairs
DISEASES
INFLAMMATION
LYMPHOKINES
MICE
RECEPTORS
SALIVARY GLANDS
Sialadenitis
TRAF6
TRAF6-deficient mice
title Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice
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