Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2

Sulindac sulfone is a metabolite of sulindac, a non-steroidal anti-inflammatory drug (NSAID), without anti-inflammatory ability. However, sulindac sulfone has been reported to significantly reduce polyps in patients with colorectal adenomatous polyposis in clinical trials. Thus, sulindac sulfone is...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-11, Vol.505 (4), p.1203-1210
Hauptverfasser:	Aono, Yuichi, Horinaka, Mano, Iizumi, Yosuke, Watanabe, Motoki, Taniguchi, Tomoyuki, Yasuda, Shusuke, Sakai, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adenosine Triphosphate - biosynthesis ANIONS Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology CELL CYCLE Cell Cycle Checkpoints Colon cancer Colonic Neoplasms - metabolism Colonic Neoplasms - pathology HT29 Cells Humans INFLAMMATION LARGE INTESTINE Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors MEMBRANE PROTEINS MITOCHONDRIA mTORC1 pathway SULFONES Sulindac - analogs & derivatives Sulindac - chemistry Sulindac - metabolism Sulindac - pharmacology Sulindac sulfone VDAC Voltage-Dependent Anion Channel 1 - antagonists & inhibitors Voltage-Dependent Anion Channel 1 - metabolism Voltage-Dependent Anion Channel 2 - antagonists & inhibitors Voltage-Dependent Anion Channel 2 - metabolism
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