Newly developed selective immunoinactivation assay revealed reduction in adipose triglyceride lipase activity in peripheral leucocytes from patients with idiopathic triglyceride deposit cardiomyovasculopathy

Triglyceride deposit cardiomyovasculopathy (TGCV) is a rare and newly identified disease among patients requiring cardiac transplantation. TGCV is characterized by cardiomyocyte steatosis and triglyceride (TG)-deposit atherosclerosis, resulting from the abnormal intracellular metabolism of TG. TGCV...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-01, Vol.495 (1), p.646-651
Hauptverfasser:	Takagi, Atsuko, Ikeda, Yasuyuki, Kobayashi, Kunihisa, Kobayashi, Kazuhiro, Ikeda, Yoshihiko, Kozawa, Junji, Miyauchi, Hideyuki, Li, Ming, Hashimoto, Chikako, Hara, Yasuhiro, Yamaguchi, Satoshi, Suzuki, Akira, Toda, Tatsushi, Nagasaka, Hironori, Hirano, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ADIPOSE TISSUE Adipose triglyceride lipase Aged ARTERIOSCLEROSIS AUTOPSY BIOLOGICAL MARKERS Biomarkers - metabolism Cardiomyopathies - blood Cardiomyopathies - enzymology DIABETES MELLITUS Enzyme Activation Female Humans Immunoenzyme Techniques - methods Leucocytes LEUKOCYTES Leukocytes - enzymology Leukocytes - immunology Lipase - immunology Lipase - metabolism LIPASES Male Middle Aged Reproducibility of Results Selective immunoinactivation assay Sensitivity and Specificity Triglyceride Triglyceride deposit cardiomyovasculopathy TRIGLYCERIDES
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