FTY720 attenuates intestinal injury and suppresses inflammation in experimental necrotizing enterocolitis via modulating CXCL5/CXCR2 axis

Necrotizing enterocolitis (NEC) remains one of the leading causes of death in neonatal infants and new therapeutic strategies for NEC are urgently required. The immunomodulatory agent FTY720 has been shown to have protective effects in various inflammatory diseases. In this study, we hypothesized th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2018-11, Vol.505 (4), p.1032-1037
Hauptverfasser:	Feng, Zongtai, Zhou, Huiting, Ma, Shurong, Guan, Xinxian, Chen, Lulu, Huang, Jie, Gui, Huan, Miao, Xinxin, Yu, Shenglin, Wang, Jiang Huai, Wang, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals ANOXIA APOPTOSIS Chemokine CXCL5 - biosynthesis Chemokine CXCL5 - metabolism CXCL5/CXCR2 axis Disease Models, Animal Enterocolitis, Necrotizing - drug therapy Enterocolitis, Necrotizing - metabolism Female Fingolimod Hydrochloride - pharmacology FTY720 INFANTS INFLAMMATION Inflammation - drug therapy Inflammation - metabolism Intestines - drug effects Intestines - injuries LIPOPOLYSACCHARIDES LYMPHOKINES Male MESSENGER-RNA MICE Mice, Inbred C57BL Necrotizing enterocolitis Neonatal mice Receptors, Interleukin-8B - biosynthesis Receptors, Interleukin-8B - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!